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Integrative Training in Therapeutic Discovery

治疗发现的综合培训

基本信息

批准号：
7293594
负责人：
LAWRENCE J. MARNETT
金额：
$ 34.38万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7293594
关键词：
11q Academia Acids Acute Admission activity Advertising Advisory Committees Affinity Age Agonist Agreement Alabama Aldosterone Alphavirus Alternative Therapies American Aminopeptidase Amphiregulin Anabolism Animal Model Antibiotics Antibodies Antipsychotic Agents Apoptosis Appendix Area Arkansas Arrhythmia Arts Authorization documentation Basic Science Behavioral Belgium Binding Biochemical Biochemistry Biological Biological Assay Biological Factors Biology Biomedical Research Biometry Biomimetics Bite Blood Vessels Bradykinin Brain Brazil Breast Breast Cancer Cell Bupropion Bypass CD3 Antigens Calcium Camping Canada Cancer Cell Growth Cancer Center Cancer Center Support Grant Carbon Carcinoma Cardiopulmonary Cardiovascular Physiology Cardiovascular system Caring Case Study Catalysis Catalytic RNA Catecholamines Cell Nucleus Cell fusion Cell membrane Cells Cellular biology Chairperson Chemical Models Chemicals Chemistry Chicago Child China Chloride Ion Chlorides Choline Cities Class Clinic Clinical Clinical Data Clinical Pharmacology Clinical Research Clinical Trials Clinical Trials Design Cloning Cocos Codon Nucleotides Cods Cognition Cognition Disorders Cognitive Cognitive Therapy Coiled-Coil Domain Collaborations Colon Colon Carcinoma Colorado Communication Communities Complement 3a Complement 3c Complement 3d Complement component C1s Complex Comprehension Computational Biology Computer Simulation Condition Consult Consultations Coronary Coupled Creatinine Creutzfeldt-Jakob Syndrome Cytoplasmic Granules DNA Data Decision Making Dentists Development Device or Instrument Development Devices Diabetes Mellitus Discipline Disease Docking Doctor of Medicine Doctor of Philosophy Dopamine Dose Double-Blind Method Drug Addiction Drug Kinetics Drug Regulations Drug effect disorder E-Cadherin ERBB2 gene Eastern Cooperative Oncology Group Eating Edema Education Educational process of instructing Eels Elements Emergency Situation Endocrine Endopeptidases Engineering Enrollment Ensure Environment Enzymes Epidermal Growth Factor Receptor Epilepsy Epithelial Epithelium Equilibrium Etiology Eugenia Evaluation Extramural Activities Facility Construction Funding Category Faculty Failure Family Fees Felis catus Fellowship Fluorescence Foundations Funding GTP-Binding Proteins GYPA gene Gambling Gelatinase B Genes Genetic Genetic Screening Genetic Transcription Genus Cola German population Germany Gland Glutamate Receptor Glutamates Glycophorin A Glycosides Goals Goldline brand of trimethobenzamide monohydrochloride Government Grant Group Meetings Growth Head Health Health Benefit Hearing Hospitals Hour Human Human Metapneumovirus Hybrids Hydrocarbons Hydrogen Peroxide Hydroxyeicosatetraenoic Acids IQ3 Idaho Illinois Immune In Situ India Indiana Individual Industry Infection Inhibitory Concentration 50 Injection of therapeutic agent Injury Institutes Interdisciplinary Study Internal Medicine International Internet Interview Investigation Investments Ions Iowa Islets of Langerhans Transplantation Israel Italy Japan Journals KAI1 gene Kansas Kentucky Kinetics Kininogenase Knowledge Korea Koreans Label Laboratories Lead Learning Left Legal patent Letters Levodopa Libraries Light Lipids Liquid substance Literature Louisiana Lung Lymphocyte Lymphoma Magnetic Resonance Imaging Magnetism Maintenance Malignant Neoplasms Malignant neoplasm of pancreas Malondialdehyde Mammary gland Master of Science Matrilysin Measures Medical Medical center Medicine Melanocytic nevus Mental Depression Mental disorders Mentors Mentorship Metabolic Biotransformation Metabolism Metabotropic Glutamate Receptors Metalloproteases Metals Metapneumovirus Methods Michigan Microbiology Mirtazapine Mississippi Missouri Modeling Mole the mammal Molecular Molecular Biology Molecular Genetics Molecular Structure Molecular and Cellular Biology Monitor Mus Muscarinic Acetylcholine Receptor Mutagenesis Mutagens Nanostructures National Institute of Allergy and Infectious Disease National Institute of Mental Health National Research Service Awards Nature Nerve Degeneration Neurobiology Neuroglia Neurologic Neurons Neurosciences Neurotransmitters Non-Steroidal Anti-Inflammatory Agents Norepinephrine Nuclear Nucleosides Numbers Obesity Object Attachment Office of the Director Ohio Oklahoma Omentum Oncology Group Online Systems Operative Surgical Procedures Oral Organic Chemistry Outcome Oxidative Stress PS 5 PTGS2 gene Pan Genus Paper Parkinson Disease Pathology Pathway interactions Patients Pediatrics Peer Review Peptide Hydrolases Peptides Performance Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacodynamics Pharmacogenetics Pharmacogenomics Pharmacologic Substance Pharmacology Pharmacy (field)Phase Phase I Clinical Trials Philosophy Phosphorus Phosphotransferases Physicians Physiological Physiology Pisum sativum Placebo Control Placebos Plaque Assay Plasmids Play Pliability Positioning Attribute Postdoctoral Fellow Potassium Potassium Channel Prevention Prevention strategy Principal Investigator Process Productivity Program Evaluation Property Prostaglandin-Endoperoxide Synthase Prostaglandins Protease Inhibitor Protein Chemistry Protein Subunits Proteins Proteomics Proteus Protocols documentation Protons Psychiatry Psychotic Disorders Publications Purines Purpose Pyrenes Qi Qualifying RNA RNA Viruses Radiation Radiation Oncology Randomized Range Rate Reaction Readiness Reagent Recombinants Recommendation Records Recruitment Activity Regulation Regulator Genes Reporting Reproduction spores Research Research Design Research Ethics Research Infrastructure Research Personnel Research Project Grants Research Training Residencies Resources Respiratory Tract Infections Retinal Review Committee Ribonucleosides Risk Risperidone Robotics Role Rotation Running S 10 SLC2A1 gene SNAP receptor Safety Sampling Scanning Schedule Schizophrenia Schools Science Scientist Sclerosis Screening Result Screening procedure Series Serine Serotonin Signal Transduction Site Site-Directed Mutagenesis Skin Sodium Solutions South Texas Spectrum Analysis Staging Stress Stromelysin 1 Structure Students Sulfides Support of Research Sweden Syndrome System Systemic Lupus Erythematosus TJ7 TNFRSF5 gene TP53 gene Taiwan Takeda brand of pioglitazone hydrochloride Techniques Technology Testing Texas Therapeutic Time Touch sensation Toxicology Training Training Activity Training Programs Training Support Transgenic Model Translating Translations Transport Process Travel United States National Institutes of Health Universities Utah Vaccines Validation Variant Veterans Virus Visit Visual Vocational Guidance Week Withdrawal Work World Health Writing Yang Yin Zebrafish abstracting adduct animation apoptolidin base career chemical genetics chromosome 5q loss college complement C3f concept cyclooxygenase 1 cyclooxygenase 2 day design drug discovery egg experience falls forest frontier gamma-Aminobutyric Acid gastrointestinal glucagon-like peptide 1 high throughput screening human disease improved in vivo indigo dye indoline ingenol inhibitor/antagonist interest irinotecan islet lecturer lectures macromolecule malignant breast neoplasm medical schools member men metabotropic glutamate receptor 4 metabotropic glutamate receptor 7 molecular imaging molecular modeling multidisciplinary named group nanoprobe neuroregulation noradrenaline transporter novel novel strategies novel therapeutics oncology oral communication p27 Cell Cycle Protein p27 Enzyme Inhibitor pandemic disease peptide analog peroxidation photoactivation posters pre-doctoral presynaptic professor programs prototype purine pyrene ranpirnase receptor repaired research study respiratory virus response sensor serotonin transporter size skills small molecule structural biology success symposium theories tool trafficking translational medicine transmission process trend tumor vector virology

项目摘要

DESCRIPTION (provided by applicant): Understanding of the mechanisms of human disease is expanding at an exponential rate and the NIH Roadmap is challenging scientists to transform this knowledge into tangible health benefits for people. As a result, teams of academic investigators are formulating therapeutic hypotheses and generating the tools with which to test them. This is creating a heed for individuals with interdisciplinary training in translational medicine and chemical biology. Experience at Vanderbilt has identified a mechanism for training graduate students and postdoctoral/fellows in which they are co-mentored by physician-scientists and chemical biologists. The current application formalizes this experience into a program that will provide integrative training in therapeutic discovery. Its goal is to train graduate students and postdoctoral/fellows in the critical steps of therapeutic discovery, including identifying an unmet medical need, considering the molecular basis of the relevant disease, framing a hypothesis for a novel therapeutic approach,- and generating the lead molecules with which to test the hypothesis. Students will be recruited into the program following their first year in graduate school and postdoctoral will be recruited directly into the program. All students and postdocs will take two courses, Foundations of Chemical Biology and Therapeutic Discovery, as well as seminars in chemical biology and clinical pharmacology. The Therapeutic Discovery.course will provide introductory training in drug discovery and describe case studies in the application of an integrative approach to the discovery of new therapeutic strategies and agents. Guest lecturers will participate in the course to highlight the latest advances in disease treatment from the perspective of the individuals who made them. A community of trainees will be developed by participation in a web-based dialog among teams in both core courses, a weekly journal club, a monthly working group, and an annual retreat. Trainees will organize a symposium of extramural speakers as part of the annual retreat. Trainees will be co-mentored by individuals with expertise in translational medicine and chemical biology and their progress will be closely monitored by the Scientific Advisory Committee of the Training Program. The quality of the training provided will be evaluated annually by both an Internal Advisory Committee and an External Advisory Committee. Substantial investments in faculty recruiting and infrastructure coupled with extensive interactions between the College of Arts and Science and the School of Medicine provides a rich environment for integrative training in therapeutic discovery at Vanderbilt.

描述（由申请人提供）：对人类疾病机制的理解正在以指数速度扩展，NIH路线图正在挑战科学家将这些知识转化为人们的有形健康益处。因此，学术研究团队正在制定治疗假设，并开发测试这些假设的工具。这为在转化医学和化学生物学方面受过跨学科培训的个人创造了一个机会。在范德比尔特的经验已经确定了一种机制，培养研究生和博士后/研究员，他们是共同辅导的物理学家，科学家和化学生物学家。目前的应用程序将这种经验正式纳入一个程序，将提供治疗发现的综合培训。它的目标是培养研究生和博士后/研究员在治疗发现的关键步骤，包括确定未满足的医疗需求，考虑相关疾病的分子基础，为新的治疗方法构建假设，并生成用于测试假设的先导分子。学生将在研究生院的第一年被招募进入该计划，博士后将直接被招募进入该计划。所有学生和博士后将参加两门课程，化学生物学和治疗发现的基础，以及化学生物学和临床药理学的研讨会。治疗发现课程将提供药物发现的入门培训，并描述应用综合方法发现新治疗策略和药物的案例研究。客座讲师将参加课程，从个人的角度突出疾病治疗的最新进展。学员社区将通过参与两个核心课程团队之间的网络对话、每周期刊俱乐部、每月工作组和年度务虚会来发展。作为年度务虚会的一部分，学员将组织一次校外演讲者研讨会。学员将由具有转化医学和化学生物学专业知识的个人共同指导，他们的进展将由培训计划的科学咨询委员会密切监测。所提供培训的质量将每年由内部咨询委员会和外部咨询委员会进行评估。在教师招聘和基础设施的大量投资，加上艺术和科学学院和医学院之间的广泛互动，为范德比尔特的治疗发现综合培训提供了丰富的环境。