Integrative Training in Therapeutic Discovery

描述(由申请者提供)：对人类疾病机制的了解正在以指数级的速度扩大，美国国立卫生研究院路线图正在挑战科学家将这些知识转化为对人们的切实健康益处。因此，学术研究团队正在制定治疗假说，并生成用于测试这些假说的工具。这为在转化医学和化学生物学方面接受跨学科培训的个人创造了一种关注。范德比尔特大学的经验已经确定了一种培养研究生和博士后/研究员的机制，在这种机制中，他们由内科科学家和化学生物学家共同指导。目前的应用程序将这种经验正式化为一个计划，该计划将提供治疗发现方面的综合培训。它的目标是在治疗发现的关键步骤中培训研究生和博士后/研究员，包括确定未得到满足的医疗需求，考虑相关疾病的分子基础，为新的治疗方法制定假说，以及产生用于检验假说的先导分子。学生将在研究生院第一年后被招募到该项目中，博士后将直接被招募到该项目中。所有学生和博士后将选修两门课程，化学生物学基础和治疗发现，以及化学生物学和临床药理学的研讨会。治疗发现课程将提供药物发现的入门培训，并描述应用综合方法发现新的治疗策略和药物的案例研究。客座讲师将参加课程，从疾病治疗的个人角度介绍疾病治疗的最新进展。通过参加两个核心课程的团队之间的网络对话、每周的期刊俱乐部、每月的工作组和年度务虚会，将建立一个受训人员社区。作为年度静修的一部分，受训者将组织一次校外演讲者座谈会。受训者将由具有转化医学和化学生物学专业知识的个人共同指导，培训计划的科学咨询委员会将密切监测他们的进展。内部咨询委员会和外部咨询委员会将每年对所提供培训的质量进行评价。在教师招聘和基础设施方面的大量投资，再加上文理学院和医学院之间的广泛互动，为范德比尔特的治疗发现综合培训提供了丰富的环境。

DESCRIPTION (provided by applicant): Understanding of the mechanisms of human disease is expanding at an exponential rate and the NIH Roadmap is challenging scientists to transform this knowledge into tangible health benefits for people. As a result, teams of academic investigators are formulating therapeutic hypotheses and generating the tools with which to test them. This is creating a heed for individuals with interdisciplinary training in translational medicine and chemical biology. Experience at Vanderbilt has identified a mechanism for training graduate students and postdoctoral/fellows in which they are co-mentored by physician-scientists and chemical biologists. The current application formalizes this experience into a program that will provide integrative training in therapeutic discovery. Its goal is to train graduate students and postdoctoral/fellows in the critical steps of therapeutic discovery, including identifying an unmet medical need, considering the molecular basis of the relevant disease, framing a hypothesis for a novel therapeutic approach,- and generating the lead molecules with which to test the hypothesis. Students will be recruited into the program following their first year in graduate school and postdoctoral will be recruited directly into the program. All students and postdocs will take two courses, Foundations of Chemical Biology and Therapeutic Discovery, as well as seminars in chemical biology and clinical pharmacology. The Therapeutic Discovery.course will provide introductory training in drug discovery and describe case studies in the application of an integrative approach to the discovery of new therapeutic strategies and agents. Guest lecturers will participate in the course to highlight the latest advances in disease treatment from the perspective of the individuals who made them. A community of trainees will be developed by participation in a web-based dialog among teams in both core courses, a weekly journal club, a monthly working group, and an annual retreat. Trainees will organize a symposium of extramural speakers as part of the annual retreat. Trainees will be co-mentored by individuals with expertise in translational medicine and chemical biology and their progress will be closely monitored by the Scientific Advisory Committee of the Training Program. The quality of the training provided will be evaluated annually by both an Internal Advisory Committee and an External Advisory Committee. Substantial investments in faculty recruiting and infrastructure coupled with extensive interactions between the College of Arts and Science and the School of Medicine provides a rich environment for integrative training in therapeutic discovery at Vanderbilt.