Neuroinflammation and neuron-glia signalling through extracellular vesicles excreted during neuronal cell death in neurodegeneration.

神经退行性变中神经元细胞死亡过程中通过细胞外囊泡分泌的神经炎症和神经元胶质信号传导。

• 批准号: 2444496
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2444496
• 关键词: Neuroinflammation; neuron; glia; signalling; through

We hypothesise that the karyoptotic microvesicles up-taken by microglia, or one of their components, act as Damage Associated Molecular Pattern (DAMP) and may trigger metabolic changes in the microglia to respond to the neuronal cell death in the surroundings. It is however unclear whether this will be a pro-or anti-inflammatory response as it is equally possible that the entrapment in microvesicles is designed to quench the pro-inflammatory response elicited by nuclear DAMPs and degrade the signal. Both hypotheses will be tested in this project.This project will useneuronal cells from differentiated neuroblastoma expressing the C9ORF72 polyPR peptides and, in some contexts, derived from C9ORF72 patient's iPSC, and the partnership between labs will enable the student to gain both molecular and cellular neuroscience skillsets in order to address our aims.

我们假设小胶质细胞吸收的核致微泡或其成分之一作为损伤相关分子模式（DAMP），并可能触发小胶质细胞的代谢变化，以应对周围环境中的神经元细胞死亡。然而，目前尚不清楚这是促炎反应还是抗炎反应，因为同样有可能的是，微泡的包裹是为了抑制核DAMPs引起的促炎反应并降低信号。这两种假设都将在本项目中进行测试。该项目将使用来自表达C9ORF72多肽的分化神经母细胞瘤的神经细胞，在某些情况下，来自C9ORF72患者的iPSC，实验室之间的合作将使学生获得分子和细胞神经科学技能，以实现我们的目标。

项目成果

Do the extracellular vesicles excreted during neuronal cell death play a neuron-glia signalling role in neurodegeneration.

神经元细胞死亡过程中分泌的细胞外囊泡在神经退行性变中发挥神经元-胶质细胞信号传导作用吗？

• DOI: 10.1002/alz.067065
• 发表时间: 2022
• 期刊: Alzheimer's & Dementia
• 作者: Barnard J