Medical workplace exposures, atopy and asthma in nurses

医疗工作场所暴露、护士的特应性和哮喘

• 批准号: 6994217
• 负责人: Maria C Mirabelli
• 金额: $ 3.56万
• 依托单位: FUNDACIO IMIM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-20 至 2009-01-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6994217
• 关键词: asthma; clinical research; disinfectants; environmental exposure; gene environment interaction; health surveys; human data; human subject; irritation /irritant; longitudinal human study; lung; nurses; occupational disease /disorder; pollution related respiratory disorder; postdoctoral investigator; respiratory disorder epidemiology; respiratory function

DESCRIPTION (provided by applicant): The main objective of this research is to evaluate exposures associated with allergy, asthma and lung function among nurses. The research will involve analysis of data from the European Community Respiratory Health Survey (ECRHS), a follow-up study of a general population sample of approximately 7000 young adults in Europe, Australia and the US. The first specific aim is to evaluate workplace exposure to respiratory irritants and sensitizers among professional nurses employed in a range of industries and medical settings, including hospitals, clinics, and private health care offices. The second specific aim is to assess whether such exposures contribute to the incidence of respiratory symptoms and lung function decline. Analyses will examine the frequency and severity of new onset asthma and allergy symptoms, exacerbation of symptoms in previously symptomatic individuals, sensitization of previously asymptomatic individuals, and behavioral consequences of the frequent and/or severe symptoms. In addition, this research will also engage the postdoctoral fellow in other asthma studies within the ECRHS, including assessing potential occupational exposures in other non industrial workplaces, such as office buildings and schools, and assessing gene-environment interactions.

描述（由申请人提供）：本研究的主要目的是评估护士与过敏、哮喘和肺功能相关的暴露。该研究将涉及欧洲共同体呼吸健康调查（ECRHS）的数据分析，这是一项对欧洲，澳大利亚和美国约7000名年轻人的一般人群样本进行的后续研究。第一个具体目标是评估在一系列行业和医疗环境（包括医院、诊所和私人医疗保健办公室）中雇用的专业护士在工作场所暴露于呼吸道刺激物和致敏物的情况。第二个具体目标是评估此类接触是否会导致呼吸道症状和肺功能下降。分析将检查新发哮喘和过敏症状的频率和严重程度、既往有症状个体的症状加重、既往无症状个体的致敏性以及频繁和/或严重症状的行为后果。此外，这项研究还将让博士后研究员参与ECRHS内的其他哮喘研究，包括评估其他非工业工作场所（例如办公楼和学校）的潜在职业暴露，以及评估基因与环境的相互作用。