Medical workplace exposures, atopy and asthma in nurses

医疗工作场所暴露、护士的特应性和哮喘

• 批准号: 7179268
• 负责人: Maria C Mirabelli
• 金额: $ 3.9万
• 依托单位: FUNDACIO IMIM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-20 至 2009-01-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7179268
• 关键词: Address; Affect; Asthma; Australia; Behavioral; Biological Products; Chemicals; Clinic; Clinics and Hospitals; Country; Data Analyses; Diagnosis; Disinfectants; Dust; Environment; Environmental Exposure; Europe; European Union; Exposure to; Fellowship; Follow-Up Studies; Frequencies; General Population; Goals; Health; Health Professional; Health Surveys; Healthcare; Home environment; Hypersensitivity; Incidence; Individual; Industry; Investigation; Irritants; Laboratory Chemicals; Latex; Location; Medical; Names; Nurses; Occupational; Occupational Exposure; Occupations; Patient Self-Report; Pharmaceutical Preparations; Pharmacologic Substance; Population; Postdoctoral Fellow; Prevalence; Questionnaires; Range; Rate; Reporting; Research; Research Project Grants; Respiratory physiology; Role; Sampling; Schools; Severities; Surveys; Symptoms; Title; Woman; Work; Workplace; atopy; design; follow-up; gene environment interaction; hospital laboratories; improved; men; respiratory; vapor; young adult

DESCRIPTION (provided by applicant): The main objective of this research is to evaluate exposures associated with allergy, asthma and lung function among nurses. The research will involve analysis of data from the European Community Respiratory Health Survey (ECRHS), a follow-up study of a general population sample of approximately 7000 young adults in Europe, Australia and the US. The first specific aim is to evaluate workplace exposure to respiratory irritants and sensitizers among professional nurses employed in a range of industries and medical settings, including hospitals, clinics, and private health care offices. The second specific aim is to assess whether such exposures contribute to the incidence of respiratory symptoms and lung function decline. Analyses will examine the frequency and severity of new onset asthma and allergy symptoms, exacerbation of symptoms in previously symptomatic individuals, sensitization of previously asymptomatic individuals, and behavioral consequences of the frequent and/or severe symptoms. In addition, this research will also engage the postdoctoral fellow in other asthma studies within the ECRHS, including assessing potential occupational exposures in other non industrial workplaces, such as office buildings and schools, and assessing gene-environment interactions.

描述(由申请人提供)：本研究的主要目的是评估护士中与过敏、哮喘和肺功能相关的暴露。这项研究将包括对欧洲共同体呼吸健康调查(ECRHS)的数据进行分析，这是对欧洲、澳大利亚和美国约7000名年轻人的总体人口样本的后续研究。第一个具体目标是评估受雇于各种行业和医疗机构(包括医院、诊所和私人保健办公室)的专业护士在工作场所暴露于呼吸道刺激物和致敏剂的情况。第二个具体目标是评估这种接触是否会导致呼吸道症状和肺功能下降的发生率。分析将检查新发哮喘和过敏症状的频率和严重程度、以前有症状的个人的症状恶化、以前没有症状的个人的敏感化，以及频繁和/或严重症状的行为后果。此外，这项研究还将让博士后研究员参与ECRHS内的其他哮喘研究，包括评估其他非工业工作场所的潜在职业暴露，如办公楼和学校，以及评估基因与环境的相互作用。