Sleep Apnea in Children with Craniofacial Anomalies

描述（由申请人提供）：颅面异常经常导致上气道受损，因此似乎是阻塞性睡眠呼吸暂停发展的诱发因素。然而，没有估计的患病率在儿童颅面临床人口的睡眠呼吸暂停的报告。本研究的目的是估计睡眠呼吸暂停在这一人群中的患病率，并在这一人群的前瞻性观察性队列研究中通过多导睡眠图确定诊断的危险因素。次要目的是验证儿童睡眠问卷（PSQ）作为颅面人群的筛查工具。长期目标包括验证该人群的睡眠呼吸暂停生活质量结局指标，并评估纵向自然病史和治疗结局。将使用多变量回归分析来量化风险因素，包括年龄、种族、症状和颅面诊断。PSQ的标准有效性将通过与队列子集中的多导睡眠图结果进行比较来评估。这项研究将允许更好地识别颅面临床人群中最有可能发生睡眠呼吸暂停的儿童，并为评估和治疗的决策过程提供信息。

DESCRIPTION (provided by applicant): Craniofacial abnormalities frequently result in upper airway compromise and thus appear to be predisposing factors for the development of obstructive sleep apnea. However, no estimates of the prevalence of sleep apnea in the pediatric craniofacial clinic population have been reported. The objectives of this research are to estimate the prevalence of sleep apnea in this population and identify risk factors for diagnosis by polysomnography in a prospective observational cohort study of this population. A secondary objective is to validate the Pediatric Sleep Questionnaire (PSQ) as a screening tool in the craniofacial population. Long term objectives include validating sleep apnea quality of life outcome measures in this population and evaluating longitudinal natural history and treatment outcomes. Multivariate regression analysis will be used to quantify risk factors including age, race, symptoms, and craniofacial diagnosis. Criterion validity of the PSQ will be assessed by comparison with polysomnography results in a subset of the cohort. This study will allow better identification of children in the craniofacial clinic population who are most at risk for developing sleep apnea and inform the decision-making process for evaluation and treatment.