Sleep Apnea in Children with Craniofacial Anomalies

描述(申请人提供)：颅面异常经常导致上呼吸道受损，因此似乎是阻塞性睡眠呼吸暂停的发展的易感因素。然而，还没有关于儿童头面部诊所人群中睡眠呼吸暂停患病率的估计。这项研究的目的是评估该人群中睡眠呼吸暂停的患病率，并在该人群的前瞻性观察队列研究中确定多导睡眠图诊断的危险因素。第二个目标是验证儿科睡眠问卷(PSQ)在颅面人群中作为筛查工具的有效性。长期目标包括验证该人群中睡眠呼吸暂停患者的生活质量结果，评估纵向自然病史和治疗结果。多元回归分析将用于量化风险因素，包括年龄、种族、症状和颅面诊断。PSQ的标准有效性将通过与队列中的一个子集的多导睡眠图结果进行比较来评估。这项研究将能够更好地识别头面部诊所人群中最有可能患睡眠呼吸暂停的儿童，并为评估和治疗的决策过程提供信息。

DESCRIPTION (provided by applicant): Craniofacial abnormalities frequently result in upper airway compromise and thus appear to be predisposing factors for the development of obstructive sleep apnea. However, no estimates of the prevalence of sleep apnea in the pediatric craniofacial clinic population have been reported. The objectives of this research are to estimate the prevalence of sleep apnea in this population and identify risk factors for diagnosis by polysomnography in a prospective observational cohort study of this population. A secondary objective is to validate the Pediatric Sleep Questionnaire (PSQ) as a screening tool in the craniofacial population. Long term objectives include validating sleep apnea quality of life outcome measures in this population and evaluating longitudinal natural history and treatment outcomes. Multivariate regression analysis will be used to quantify risk factors including age, race, symptoms, and craniofacial diagnosis. Criterion validity of the PSQ will be assessed by comparison with polysomnography results in a subset of the cohort. This study will allow better identification of children in the craniofacial clinic population who are most at risk for developing sleep apnea and inform the decision-making process for evaluation and treatment.