Reproductive interference for insect control

昆虫控制的生殖干扰

• 批准号: 2445339
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2445339
• 关键词: Reproductive; interference; insect; control

Insect pests are a persistent and growing threat to human livelihoods and health because they damage economically important crops and spread disease. The pressing global challenge of combating such pests is also being exacerbated by the climate crisis, leading to migration of insect vectors into previously unoccupied conurbations, creating new human-pest exposures. The project will focus on reproductive interference - whereby courtship and copulation of one species / population is interrupted or disturbed by another. In the context of insect control this is usually referred to as satyrization and it works because the consequences (particularly costs) of hybrid mating are often unidirectional leading to the competitive exclusion of a harmful species (or population) by a more benign one.The project is a collaboration with the Earlham and Pirbright Institutes, world-leading research centres for bioinformatics and the development of genetic technologies, respectively. A test case for insect control via satyrization in the fruitfly model will be developed to identify the loci and regulatory mechanisms contributing to satyrization as well as the underpinning signal and receivers.

害虫对人类生计和健康构成持续且日益严重的威胁，因为它们损害经济上重要的作物并传播疾病。气候危机也加剧了全球防治此类害虫的紧迫挑战，导致昆虫媒介迁移到以前无人居住的大都市，造成新的人类害虫暴露。该项目将重点关注生殖干扰——一个物种/种群的求爱和交配被另一个物种/种群打断或干扰。在昆虫控制的背景下，这通常被称为“色狼化”，它之所以有效，是因为杂交交配的后果（特别是成本）通常是单向的，导致有害物种（或种群）被更良性的物种（或种群）竞争性排除。该项目是与厄勒姆研究所和皮尔布赖特研究所合作，这两个研究所分别是世界领先的生物信息学和遗传技术开发研究中心。将开发一个通过果蝇模型中的 Satyrization 控制昆虫的测试用例，以确定有助于 Satyrization 的基因座和调节机制以及基础信号和接收器。