BRAIN INJURY IN TORTURE SURVIVORS: MENTAL HEALTH IMPACT

酷刑幸存者的脑损伤：对心理健康的影响

• 批准号: 7048423
• 负责人: RICHARD MOLLICA
• 金额: $ 5.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-15 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7048423
• 关键词: behavioral /social science research tag; brain injury; clinical research; functional ability; head /neck injury; human subject; long term survivor; mental health epidemiology; neuropsychological tests; southeast Asia; trauma; war /peace

EXCEED THE SPACE PROVIDED. The proposed research is the first community study of a population of torture survivors that investigates the impact of head injury, common in torture, on psychiatric and functional outcomes. The study will determine the amount of torture and head injury events in Vietnamese torture survivors. It will test the hypotheses that a) torture survivors with head injury have higher levels of psychiatric symptoms and functional impairment than torture survivors or controls without head injury; b) torture survivors with head injury will have brain abnormalities on neuropsychological testing and neuroimaging distinct from survivors and controls without head injury; and c) torture survivors with depression and PTSD will have brain abnormalities on neuropsychological testing and neuroimaging distinct from survivors and controls without these diagnoses. The design is a cross-sectional study of a complete census of all Vietnamese torture survivors (i.e., ex-political detainees) on the roster of Massachusetts' leading Vietnamese resettlement agency (n = 400) and a control group of similar age/gender Vietnamese immigrants who are not ex-political detainees, have not been tortured and have not had head injury (n=125). All subjects will receive an initial survey which measures personal and environmental risk factors, self-report of torture and head injury, and psychiatric and functional outcomes. Next, all subjects will receive culture-fair neuropsychological tests capable of detecting deficits including executive function, complex attention and memory. Based on the results of the general survey, the sample will be divided into six comparison groups: torture with head injury with/without psychiatric symptoms, torture without head injury with/without psychiatric symptoms, controls with/without psychiatric symptoms. Subjects from each of the six groups (n=140) will be randomly selected to undergo neuroimaging (brain MRI and DSC fMRI). Graphical methods, descriptive statistics, ANOVA, logistic regression, and structural equation models will be used to test the hypotheses. PERFORMANCE SITE ========================================Section End===========================================

超出所提供的空间。 拟议的研究是对酷刑幸存者群体的第一次社区研究，调查酷刑中常见的头部受伤对精神和功能结果的影响。这项研究将确定越南酷刑幸存者遭受酷刑和头部受伤事件的数量。它将检验以下假设：（a）有头部受伤的酷刑幸存者的精神症状和功能损害程度高于酷刑幸存者或没有头部受伤的对照组;（B）有头部受伤的酷刑幸存者在神经心理测试和神经成像方面的大脑异常情况与没有头部受伤的幸存者和对照组不同;和c）患有抑郁症和PTSD的酷刑幸存者在神经心理学测试和神经成像上将具有与没有这些诊断的幸存者和对照不同的大脑异常。该设计是对所有越南酷刑幸存者进行全面普查的横截面研究（即，在马萨诸塞州主要越南移民安置机构名册上的前政治拘留者（n = 400）和年龄/性别相似的越南移民对照组（n=125），这些越南移民不是前政治拘留者，没有受到酷刑，也没有头部受伤。所有受试者将接受初步调查，衡量个人和环境风险因素，酷刑和头部受伤的自我报告，以及精神和功能结果。接下来，所有受试者将接受文化公平的神经心理学测试，能够检测包括执行功能，复杂注意力和记忆力在内的缺陷。根据一般性调查的结果，将样本分为六个对照组：有/无精神症状的头部受伤酷刑组、有/无精神症状的头部没有受伤酷刑组、有/无精神症状的对照组。将随机选择6组中的每一组（n=140）的受试者进行神经影像学检查（脑MRI和DSC fMRI）。将使用图形方法、描述性统计、ANOVA、逻辑回归和结构方程模型来检验假设。性能现场=

项目成果

The mental health sequelae of traumatic head injury in South Vietnamese ex-political detainees who survived torture.

酷刑幸存的南越前政治犯因颅脑外伤造成的心理健康后遗症。

• DOI: 10.1016/j.comppsych.2014.04.014
• 发表时间: 2014
• 期刊: Comprehensive psychiatry
• 影响因子: 7.3
• 作者: Mollica,RichardF;Chernoff,MiriamC;MeganBerthold,S;Lavelle,James;Lyoo,InKyoon;Renshaw,Perry
• 通讯作者: Renshaw,Perry