MASTER OF SCIENCE DEGREE IN CLINICAL INVESTIGATION

描述(由申请人提供)： 这项申请是圣安东尼奥的德克萨斯大学健康科学中心(UTHSCSA)临床研究课程奖(NHLBI K30 HL04159)的竞争续订。在过去的三年里，我们成功地建立了一个新的临床调查理学硕士(MSCI)学位课程，并招收了26名不同的学生；5名(19.2%)已经成功地获得了同行评议的拨款。通过这项申请，我们寻求实现两个具体目标：1)提高和扩大针对UTHSCSA所有5所学校的博士后、毕业生和教职员工的临床研究培训的质量，以及2)进一步增加学生在种族和专业背景方面接受临床研究培训的多样性。我们受训人员的“实验室”是综合临床研究中心，这是一个由NIH资助的中心，位于我们的一家教学医院。通过与我们的拉美裔卓越中心建立联系，接受临床研究培训的不同种族学生的数量将继续增加，特别是墨西哥裔美国人和其他拉美裔群体。一旦接受培训，该项目的毕业生将成为设计和实施以患者为中心的调查的专家。MSCI计划的导师是在分子生物学、蛋白质化学、细胞生物学和临床研究方面拥有活跃计划的教职员工，他们在成功实施研究计划、研究教育计划和获得校外资助方面拥有公认的专业知识。由于大多数医学博士在这一领域缺乏博士项目所特有的正规教学培训，我们已经建立了一个有组织的项目，为我们的学员未来独立的临床研究人员做准备。MSCI考生在参加11门综合性教学课程的同时，完成了两年多的指导研究项目：(A)研究方法(3个学期)；(B)生物统计学(3个学期)；(C)负责任的研究行为(1个学期)；(D)将分子生物学融入临床研究(1个学期)；(E)数据管理和质量控制(1个学期)；(F)科学写作(1个学期)；以及卫生服务研究(1个学期-本申请中建议的一门新课程)。我们的目标是不断改进研究人员的准备工作，使他们在不同的文化背景下进行杰出的临床研究。MSCI计划的有效性将通过监测一组具有凝聚力的4项主要成果来确定。这些结果是：(A)继续从事临床研究事业的毕业生(及其角色)；(B)成功竞争职业发展和研究奖项的毕业生；(C)毕业生的科学同行评议出版物；(D)从事指导其他临床研究人员的毕业生。

DESCRIPTION (provided by applicant): This application is a competing renewal for the University of Texas Health Science Center at San Antonio's (UTHSCSA) Clinical Research Curriculum Award (NHLBI K30 HL04159). Over the past 3 years we successfully established a new Masters of Science in Clinical Investigation (MSCI) Degree Program and enrolled a diverse group of 26 students; 5 (19.2%) have already been successful in obtaining peer reviewed grant funding. With this application we seek to achieve 2 specific aims: 1) enhance and expand the quality of clinical research training for post-doctoral students, graduates, and faculty from all 5 of the UTHSCSA's schools, and 2) further increase the diversity of the students, in ethnicity and professional background, trained in the conduct of clinical research. The 'laboratory' for our trainees is the General Clinical Research Center, an NIH-funded center located in one of our teaching hospitals. By linking with our Hispanic Centers of Excellence, the number of ethnically diverse students, particularly Mexican-Americans and other Hispanic groups, trained in clinical research will continue to increase. Once trained, this program's graduates will be expert in the design and conduct of patient-oriented investigations. The preceptors for the MSCI program are faculty members with active programs in molecular biology, protein chemistry, cell biology and clinical research, and who have proven expertise in running successful research programs, research education programs, and in obtaining extramural grant support. Since most MDs lack the formal didactic training characteristic of PhD programs in this arena, we have established an organized program to prepare our trainees as future independent clinical researchers. MSCI candidate complete a mentored research project over 2 years while participating in an integrated set of 11 didactic courses: (a) Research Methods (3 semesters); (b) Biostatistics (3 semesters); (c) Responsible Conduct of Research (1 semester); (d) Integration of Molecular Biology into Clinical Research (1 semester); (e) Data management and Quality Control (1 semester); (f) Scientific Writing (1 semester); and Health Services Research (1 semester - a new course proposed in this application). Our goal is to continually improve the preparation of investigators skilled in the conduct of outstanding clinical research in culturally diverse settings. MSCI program effectiveness will be ascertained by monitoring a cohesive set of 4 primary outcomes. These outcomes are the number of: (a) graduates who continue in clinical research careers (and their roles); (b) graduates who successfully compete for career development and research awards; (c) scientific peer-reviewed publications of the graduates; (d) graduates engaged in mentoring other clinical investigators.