MASTER OF SCIENCE DEGREE IN CLINICAL INVESTIGATION

描述（由申请人提供）： 本申请是德克萨斯大学圣安东尼奥健康科学中心（UTHSCSA）临床研究课程奖（NHLBI K30 HL 04159）的竞争性更新。 在过去的3年中，我们成功地建立了一个新的临床研究（MSCI）学位课程的科学硕士，并招收了26名学生的多元化群体; 5（19.2%）已经成功地获得了同行评审的赠款资金。 有了这个应用程序，我们寻求实现2个具体目标：1）提高和扩大博士后学生，毕业生和教师的临床研究培训的质量，从UTHSCSA的所有5所学校，和2）进一步增加学生的多样性，在种族和专业背景，在临床研究的进行培训。 我们学员的“实验室”是综合临床研究中心，这是一个由NIH资助的中心，位于我们的一家教学医院内。 通过与我们的西班牙裔卓越中心联系，在临床研究中接受培训的种族多样化学生，特别是墨西哥裔美国人和其他西班牙裔群体的数量将继续增加。 一旦接受培训，该计划的毕业生将成为设计和进行以患者为导向的调查的专家。 MSCI计划的导师是在分子生物学，蛋白质化学，细胞生物学和临床研究方面具有活跃计划的教师，他们在运行成功的研究计划，研究教育计划和获得校外资助方面具有公认的专业知识。 由于大多数医学博士缺乏在这个竞技场的博士课程的正式教学训练的特点，我们已经建立了一个有组织的计划，准备我们的学员作为未来的独立临床研究人员。 MSCI候选人在2年内完成一个指导研究项目，同时参加一套11门教学课程：（a）研究方法（3个学期）;（B）生物统计学（3个学期）;（c）负责任的研究行为（1学期）;（d）将分子生物学纳入临床研究（1个学期）;（e）数据管理和质量控制（1个学期）;（f）科学写作（1个学期）;和卫生服务研究（1个学期-本申请中提出的新课程）。 我们的目标是不断提高研究人员的准备熟练在文化多样性环境中进行出色的临床研究。 MSCI计划的有效性将通过监测一组有凝聚力的4个主要结果来确定。这些成果是：（a）继续从事临床研究职业的毕业生人数（及其作用）;（B）成功竞争职业发展和研究奖项的毕业生人数;（c）毕业生发表经同行评审的科学出版物的人数;（d）从事指导其他临床研究者的毕业生人数。

DESCRIPTION (provided by applicant): This application is a competing renewal for the University of Texas Health Science Center at San Antonio's (UTHSCSA) Clinical Research Curriculum Award (NHLBI K30 HL04159). Over the past 3 years we successfully established a new Masters of Science in Clinical Investigation (MSCI) Degree Program and enrolled a diverse group of 26 students; 5 (19.2%) have already been successful in obtaining peer reviewed grant funding. With this application we seek to achieve 2 specific aims: 1) enhance and expand the quality of clinical research training for post-doctoral students, graduates, and faculty from all 5 of the UTHSCSA's schools, and 2) further increase the diversity of the students, in ethnicity and professional background, trained in the conduct of clinical research. The 'laboratory' for our trainees is the General Clinical Research Center, an NIH-funded center located in one of our teaching hospitals. By linking with our Hispanic Centers of Excellence, the number of ethnically diverse students, particularly Mexican-Americans and other Hispanic groups, trained in clinical research will continue to increase. Once trained, this program's graduates will be expert in the design and conduct of patient-oriented investigations. The preceptors for the MSCI program are faculty members with active programs in molecular biology, protein chemistry, cell biology and clinical research, and who have proven expertise in running successful research programs, research education programs, and in obtaining extramural grant support. Since most MDs lack the formal didactic training characteristic of PhD programs in this arena, we have established an organized program to prepare our trainees as future independent clinical researchers. MSCI candidate complete a mentored research project over 2 years while participating in an integrated set of 11 didactic courses: (a) Research Methods (3 semesters); (b) Biostatistics (3 semesters); (c) Responsible Conduct of Research (1 semester); (d) Integration of Molecular Biology into Clinical Research (1 semester); (e) Data management and Quality Control (1 semester); (f) Scientific Writing (1 semester); and Health Services Research (1 semester - a new course proposed in this application). Our goal is to continually improve the preparation of investigators skilled in the conduct of outstanding clinical research in culturally diverse settings. MSCI program effectiveness will be ascertained by monitoring a cohesive set of 4 primary outcomes. These outcomes are the number of: (a) graduates who continue in clinical research careers (and their roles); (b) graduates who successfully compete for career development and research awards; (c) scientific peer-reviewed publications of the graduates; (d) graduates engaged in mentoring other clinical investigators.