Core--Laboratory Services

在过去的五年里，加州大学伯克利分校儿童环境健康研究中心的实验室服务核心(实验室核心)为创建大型生物库提供了基础设施。核心制定了样本收集、处理、处理和银行处理的标准操作程序。该中心还制定和实施了一项质量管理计划，设计了一个定制数据库和全面的数据跟踪程序，并建立和验证了研究生物终点的高通量方法。 在接下来的五年里，中心的主要目标将是继续并扩大其在支持中心研究项目方面的作用。核心工作人员将履行关键的实验室职能，包括收集额外的生物样本，并确保对已经储存的样本进行最佳存储。该核心将监督新收集的标本的收集、标记、处理和储存方案的开发和实施，包括活细胞冷冻保存和细胞因子分析的先进程序。该中心将协调中心外地办事处、中央生物库和疾病控制和预防中心(CDC)等合作分析实验室之间的所有样本运输。核心将继续确保遵守与样品收集、处理、运输、储存和数据管理的所有方面有关的质量保证和质量控制程序。 此外，中心生物库将成为新成立的加州大学公共卫生学院生物库的一个部门。通过汇集基础设施和资源，核心将增强和扩大其为中心的研究项目提供最先进的实验室支持的能力。

For the past five years, the Laboratory Service Core (Laboratory Core) of the Center for Children's Environmental Health Research at the University of California, Berkeley, has provided the infrastructure for the creation of a large biorepository. The Core has developed standard operating procedures for sample collection, handling, processing, and banking. The Core has also developed and implemented a Quality Management Plan, designed a custom database and comprehensive data tracking procedures, and established and validated high-throughput methods to study biological endpoints. Over the next five years, the primary goal of the core will be to continue and expand its role in support of the Center's research projects. Core staff will perform key laboratory functions, including collecting additional biological samples and assuring optimal storage of already banked samples. The Core will oversee the development and implementation of protocols for the collection, labeling, processing, and banking of newly collected specimens, including advanced procedures for viable cell cryopreservation and cytokine analysis. The Core will coordinate shipment of all samples between the Center field office, central biorepository and collaborating analytical laboratories, such as the Centers for Disease Control and Prevention (CDC). The Core will continue to ensure compliance with quality assurance and quality control procedures related to all aspects of sample collection, processing, shipping, storage, and data management. In addition, the Center Biorepository will become a division of the newly created University of California, School of Public Health Biorepository. By pooling infrastructure and resources, the Core will enhance and expand its ability to provide state of the art laboratory support to the Center's research projects.