Pesticide Exposure Pathways

农药暴露途径

• 批准号: 6960244
• 负责人: MICHAEL G YOST
• 金额: $ 12.99万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-07 至 2008-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6960244
• 关键词: agriculture; agriculture worker; air sampling /monitoring; child (0-11); clinical research; developmental nutrition; dosage; environmental contamination; environmental exposure; environmental health; environmental toxicology; field study; food contamination; human subject; mathematical model; model design /development; occupational hazard; organophosphorus insecticide; parent offspring interaction; pesticide biological effect; pesticide residues; urinalysis

Description (provided by applicant): Mechanisms of exposure for children's susceptibility are defined by types and frequency of exposures, age-specific behaviors, and temporal and toxicokinetic exposure considerations. The Pesticide Exposure Pathways Research Project focuses on the physical and behavioral mechanisms of children's pesticide exposures. These detailed assessments fit well with the other field and laboratory-based Center projects. The Community-Based Participatory Research Project is evaluating the mechanisms of children 's exposure through occupational takehome and dietary exposures. Their assessments fit well with the detailed spray drift and activity pattern assessments of the Pesticide Exposure Pathways Project. Together, both projects will inform the Exposure Assessment and Risk Characterization Cores and provide a real-life context for the laboratory-based studies. The results of this project will feed back to inform the Community-Based Participatory Research Project and also inform the activities of the Risk Characterization and the Community Outreach and Translation Cores to reduce exposures.

描述（由申请人提供）：儿童易感性的暴露机制由暴露的类型和频率、年龄特异性行为以及时间和毒性动力学暴露因素定义。农药暴露途径研究项目侧重于儿童农药暴露的生理和行为机制。这些详细的评估与其他以实地和实验室为基础的中心项目非常吻合。以社区为基础的参与性研究项目正在通过职业带回家和饮食接触来评估儿童接触的机制。他们的评估与农药暴露途径项目详细的喷雾漂移和活动模式评估非常吻合。这两个项目将共同为暴露评估和风险表征核心提供信息，并为基于实验室的研究提供现实环境。该项目的结果将反馈给基于社区的参与性研究项目，并为风险表征和社区外展和翻译核心活动提供信息，以减少暴露。