Exploring the Function of Breast Cancer-Associated Variants in Long Non-Coding RNAs

探索长非编码 RNA 中乳腺癌相关变异的功能

• 批准号: nhmrc : 1058421
• 负责人: A/Pr Juliet French
• 金额: $ 33.45万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-function-breast-coding-rnas/454674
• 关键词: Exploring; Function; Breast; Cancer; Associated

Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel avenues for therapy.

最近的研究已经确定了人类基因组中DNA序列变异与乳腺癌风险增加相关的区域。这些区域中有几个不包含任何已知的蛋白质编码基因，这表明非蛋白质编码基因可能是相关风险的原因。本研究的目的是鉴定和鉴定这些非编码基因。了解这些新基因的序列变异如何导致乳腺癌，将为治疗提供新的途径。