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Exploring the Function of Breast Cancer-Associated Variants in Long Non-Coding RNAs

Exploring the Function of Breast Cancer-Associated Variants in Long Non-Coding RNAs
探索长非编码 RNA 中乳腺癌相关变异的功能
批准号:
nhmrc : 1058421
负责人:
A/Pr Juliet French
金额:
$33.45万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

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中文摘要
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英文摘要
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel avenues for therapy.
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会议论文
Post-GWAS Functional Characterisation of Breast Cancer Susceptibility Loci
Identification of germline variation that predicts progression free survival following chemotherapy for advanced ovarian cancer
Functional analysis of breast cancer susceptibility regions
Identifying long-range regulatory elements of the breast cancer susceptibility gene, BRCA1
  • 批准号:
    nhmrc : 631381
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $40.86万
  • 财政年份:
    2010
  • 负责人:
    A/Pr Juliet French
  • 依托单位:
国内基金
海外基金
原生动物四膜虫生殖小核(germline nucleus)体功能(somatic function)的分子基础研究