Post-GWAS Functional Characterisation of Breast Cancer Susceptibility Loci

乳腺癌易感性位点的 GWAS 后功能表征

• 批准号: nhmrc : 1058415
• 负责人: A/Pr Juliet French
• 金额: $ 50.99万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/post-gwas-functional-susceptibility-loci/454673
• 关键词: Post; GWAS; Functional; Characterisation; Breast

Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known genes, suggesting that regulatory DNA sequences are responsible for the associated risk. The aim of this proposal is to identify and characterise these DNA sequences. Understanding how sequences variations in these regions contribute to breast cancer will provide novel avenues for therapy.

最近的研究已经确定了人类基因组中 DNA 序列变异与乳腺癌风险增加相关的区域。其中几个区域不包含任何已知基因，表明调控 DNA 序列是造成相关风险的原因。该提案的目的是识别和表征这些 DNA 序列。了解这些区域的序列变异如何导致乳腺癌将为治疗提供新的途径。