Identifying long-range regulatory elements of the breast cancer susceptibility gene, BRCA1

鉴定乳腺癌易感基因 BRCA1 的长程调控元件

• 批准号: nhmrc : 631381
• 负责人: A/Pr Juliet French
• 金额: $ 40.86万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-long-range-gene-brca1/80940
• 关键词: Identifying; long; range; regulatory; elements

BRCA1 is a breast cancer susceptibility gene implicated in both familial and sporadic breast cancers. The mechanisms controlling BRCA1 expression are poorly understood. We will identify DNA sequences critical for regulation of the BRCA1 gene. We hypothesise that these regions are mutational hot spots conferring an increased breast cancer risk. A better understanding of the pathways responsible for promoting BRCA1-associated breast cancer will provide important diagnostic and treatment targets.

BRCA1是家族性和散发性乳腺癌的易感基因。控制BRCA1表达的机制知之甚少。我们将确定对BRCA1基因调控至关重要的DNA序列。我们假设这些区域是增加乳腺癌风险的突变热点。更好地了解促进BRCA1相关乳腺癌的途径将提供重要的诊断和治疗目标。