Laser control over crystal nucleation

激光控制晶体成核

• 批准号: 2450227
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2450227
• 关键词: Laser; control; over; crystal; nucleation

The research programme will investigate and exploit the laser-induced phase-separation and nucleation (LIPSaN) technique in solutions of small molecules and peptides. We will use differential scanning calorimetry (DSC) and dynamic light scattering (DLS) to characterise the liquid-liquid phase diagram and use ternary solutions to control the phase behaviour. The probability of crystal nucleation will be mapped out and analysed in terms of classical nucleation theory as well as the effects of (hidden) liquid-liquid phase separation. Armed with this knowledge, LIPSaN will be used to induce and ultimately control nucleation. The project will be supervised by Prof. Klaas Wynne (chemical physics, optics, spectroscopy) and Dr. Adrian Lapthorn (biochemistry, protein crystallisation) and is supported by an ERC Advanced grant that started 1 September 2019.

该研究计划将研究和利用小分子和肽溶液中的激光诱导相分离和成核（LIPSaN）技术。我们将使用差示扫描量热法（DSC）和动态光散射（DLS）来绘制液-液相图，并使用三元溶液来控制相行为。晶体成核的概率将被绘制出来，并根据经典成核理论以及（隐藏的）液-液相分离的影响进行分析。有了这些知识，LIPSaN将用于诱导并最终控制成核。 该项目将由Klaas韦恩教授（化学物理，光学，光谱学）和Adrian Lapthorn博士（生物化学，蛋白质结晶）监督，并由2019年9月1日开始的ERC高级资助支持。