Seizure Location Using Signal Processing Techniques

描述（由申请人提供）：为P.I.设计了一个研究和职业发展计划，旨在设计新的方法来解释癫痫患者的长期颅内脑电图（EEG）。颅内监测已被确立为切除性癫痫手术前癫痫发作定位的最具体方法。现有的解释方法已被证明不足以解释源自新皮层的癫痫发作。来自信号处理领域的定量技术可以应用于脑电图信号，以揭示时空模式，为癫痫发作的起源提供线索。将绘制癫痫患者大脑中神经元网络组织的异常图谱，并通过评估从正常猕猴获得的可比记录的同步性和电流源密度分析来验证异常发现。这些发现，以及癫痫发作期间脑电图记录的行为，将被研究以定义脑电图模式，并深入了解其癫痫发生的潜在机制。这将为制定准确解释颅内记录的方法提供一个框架。一个正式的培训计划已经为私家侦探量身定制了她的学术需求，补充了她之前的临床培训和工程和数学的经验。这将包括：电生理学、信号处理、灵长类动物研究和临床癫痫学专家的指导，以及生物医学信号处理、统计学和研究伦理方面的课程。这个协调的研究和培训项目的目标是完成私家侦探作为独立研究人员的职业准备，具备进行多学科合作调查的技能和为电生理学和癫痫研究确定新方向的发展能力。

DESCRIPTION (provided by applicant): A program of research and career development has been designed for the P.I. to devise new methods for interpreting long-term intracranial electroencephalograms (EEG) of epilepsy patients. Intracranial monitoring has been established as the most specific method of seizure localization prior to resective epilepsy surgery. Existing methods of interpretation have proven inadequate for seizures originating in neocortex. Quantitative techniques drawn from the field of signal processing can be applied to EEG signals to reveal spatio- temporal patterns that provide clues to the seizure origin. Mapping of abnormalities in neuronal network organization in the brains of epilepsy patients will be performed, with validation of abnormal findings by evaluation of synchrony and current source density analysis in comparable recordings obtained from normal macaque monkeys. These findings, together with the behavior of EEG recordings during epileptic seizures, will be studied to define ictal EEG patterns and gain insight into their underlying mechanisms of epileptogenesis. This will provide a framework for the formulation of methods for the accurate interpretation of intracranial recordings. A formal training program has been designed for the P.I. specifically tailored to her academic needs, complementing her prior clinical training and experience in engineering and mathematics. This will include: mentoring by experts in electrophysiology, signal processing, primate studies and clinical epileptology, and course work in biomedical signal processing, statistics and research ethics. The goal of this coordinated program of research and training is to complete the preparation of the P.I. for a career as an independent researcher, with the skills to perform multidisciplinary collaborative investigation and a developed capacity to define new directions for research in electrophysiology and epilepsy.