Human Papillovirus Testing in Adolescents

描述(申请人提供)：杰西卡·卡恩，医学博士，M.P.H.，已完成 青春期医学和妇科的临床培训 波士顿医院，哈佛大学公共卫生学院公共卫生硕士学位 1999年。随后，她加入了儿童医院医学中心的教职员工队伍， 从事以专利为导向的研究。大卫·伯恩斯坦，医学博士，项目 赞助商，带来了关于Virai STI的临床研究专业知识， NIH提供了大量资金，并有指导新调查人员的经验。这个 赞助商、咨询委员会成员和合作者组成一个多学科 拥有不同专业知识的研究团队。研究环境将支持 教学计划，包括相关的高级质量课程和 量化方法，研究伦理培训，以及与其他人的互动 临床调查员。卡恩博士的总体职业目标是成为一名 独立的临床调查员，他的工作将集中在预防 人乳头瘤病毒感染与宫颈癌。她计划通过以下方式实现这一目标 翻译关于1)HPV感染的生物医学方面的数据和 2)对青少年进行HPV检测的心理和行为影响- 预防宫颈癌的具体、有效的临床策略 个人和人口水平。这项研究计划的目标是 探讨HPV检测在宫颈癌预防中的潜在作用 针对青少年的节目。实现的具体目标和方法 每个目标都会随之而来。 目的1确定青少年巴氏涂片随访的预测因素。目标1 将使用490个城市样本中现有的前瞻性数据进行检验， 不同种族的青少年。 目的2检测阳性HPV对心理和行为的影响 在女大学生中进行测试。目标2将使用现有的 来自608名不同种族的大学女生样本的纵向数据。 目的3探讨与心理、行为和人际关系相关的 青少年人乳头瘤病毒和巴氏涂片检测结果分析目标3、4和5 将使用前瞻性收集的定性和定量的方法进行检查 对250名HPV感染高危的城市青春期女孩进行了抽样调查。 目的4确定人乳头瘤病毒DNA自我检测的准确性和可接受性 在上面的城市青春期女孩样本中。 目的5确定持续和持续的累积患病率和比率 人乳头瘤病毒感染的消退及检测结果与宫颈的相关性 细胞学，在上面的城市青春期女孩样本中。

DESCRIPTION (provided by applicant): Jessica Kahn, M.D., M.P.H., completed clinical training in Adolescent Medicine and Gynecology at Children's Hospital, Boston and an MPH degree at the Harvard School of Public Health in 1999. She then joined the faculty at Children's Hospital Medical Center to pursue a career in patent-oriented research. David Bernstein, MD, the project Sponsor, brings expertise in clinical research regarding viraI STI, has extensive NIH funding, and has experience mentoring new investigators. The Sponsor, Advisory Board Members and Collaborators form a multidisciplinary research team with diverse expertise. The research environment will support a didactic program that includes relevant courses in advanced qualitative and quantitative methods, training in research ethics, and interaction with other clinical investigators. Dr. Kahn's overall career goal is to become an independent clinical investigator whose work will focus on the prevention of HPV infection and cervical cancer. She plans to achieve this goal through the translation of data regarding 1) the biomedical aspects of HPV infection and 2) the psychological and behavioral impact of testing for HPV into adolescent- specific, effective clinical strategies for cervical cancer prevention at the individual and population levels. The objective of this research plan is to explore the potential role of HPV testing in cervical cancer prevention programs targeting adolescents. The specific aims and methods for achieving each aim follow. Aim 1 To determine predictors of Pap smear foIlow-up in adolescents. Aim 1 will be examined using existing prospective data from a sample of 490 urban, racially diverse adolescents. Aim 2 To examine the psychological and behavioral effects of positive HPV testing in female college students. Aim 2 will be examined using existing longitudinaI data from a sample of 608 racially diverse college women. Aim 3 To explore the psychological, behavioral, and relationship-related effects of positive HPV and Pap smear testing in adolescents. Aims 3, 4, and 5 will be examined using prospectively collected, qualitative and quantitative data in a sample of 250 urban adolescent girls at high risk for HPV infection. Aim 4 To determine the accuracy and acceptability of self-testing for HPV DNA in the above sample of urban adolescent girls. Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls.