KL2 Training Program

联系PD/PI：Heubi，James E Inst-Career-Dev-001（001） I.机构职业发展核心（KL2） 摘要 辛辛那提大学临床和转化科学与培训中心（CCTST） 在培训KL2学者方面有着出色的成就记录。KL2计划任命了24名学者 (50自2009年以来，来自不同学科的妇女占12.5%，代表性不足）（每年2人，为期2至3年 任命）。学者们共发表了674篇手稿，提出了792篇摘要， 在国家和国际科学会议上举办讲习班。20名毕业生中，95%仍在进行 临床和转化研究（CTR），100%担任主要研究者（PI）或共同研究者（Co-PI）。 外部资助CTR补助金的研究者（Co-I）：20%已过渡到职业生涯的PI 发展奖（CDA），联邦独立赠款的PI占65%，CDA或联邦的PI占75% 独立补助金，以及联邦独立补助金的95%给PI或Co-I。毕业生曾担任 7个R01，3个国防部独立拨款，4个R21，1个R03，2个R40，1个R25，1个R15，1个U19，2个K23，1个 K25和1美国心脏协会CDA。他们担任3个U01的研究中心PI。直接成本的总和 奖学金产生的收入为109，286，934美元。我们的团队越来越意识到需要解决 培养初级研究人员面临的挑战包括：1）招募和培养多样化的研究人员; 2)培训他们能够胜任广泛的核心CTR技能; 3）准备他们成功地 进行团队科学; 4）确保他们实现可持续和独立的职业生涯; 5）培养活力 （专业参与，承诺和履行），尽管学术教师的倦怠水平不断上升; 6）鼓励他们将利益相关者的优先事项纳入研究，并传播研究成果，以提高 健康成果。因此，我们设计了我们的KL 2学者计划，以解决这些挑战，使用 以证据为基础的战略，以实现以下具体目标：1）培养下一代临床和 通过指导研究经验，核心方法和技能发展的翻译研究人员，以及 量身定制的体验式学习机会; 2）培养敬业的、多样化的初级调查员， 可持续的翻译研究事业; 3）促进学者研究的翻译， 整个生命周期的健康结果。我们计划在CTSA中心和一个 使用3D技术（开发、演示和 传播）的方法。我们设计了严格的计划评估计划，包括NCATS共同 指标，纳入了广泛的研究伦理培训，并制定了一个全面的计划， 增加招聘和留住在生物医学研究中代表性不足的研究人员。 成功将通过以下结果来衡量：1）我们招募多样化，充满活力的学者，2）学者 获得资助并在高影响力的期刊上发表作品; 3）学者开展持续的独立研究 4）学者的研究成果改善了健康状况。 常用缩略语：AHC-学术健康中心; BERD-生物统计学、流行病学和 研究设计; CCHMC-辛辛那提儿童医院医学中心; CCTST-临床和 转化科学与培训; CDA-职业发展奖; CIS-改进中心 科学; CTR-临床和转化研究; IDP-个人发展计划; OAACD-办公室 学术事务和职业发展; PTC-试点转化和临床研究核心; TWD- 转化劳动力开发; UCCOM-辛辛那提大学医学院; URM- 任职人数偏低的少数群体 第九百一十五页 项目总结/摘要 联系PD/PI：Heubi，James E Inst-Career-Dev-001（001） 叙事 NCATS KL 2职业发展计划是开发下一代临床医学的基础。 和翻译研究人员，并确保他们实现职业成功和研究独立。的 辛辛那提大学临床和转化科学与培训中心拥有良好的记录 在培训KL2学者的成就：20名毕业生中，95%仍在进行临床和 翻译研究，100%曾担任外部资助的主要研究者或合作研究者 奖学金产生的直接费用总额为109，286，934美元。我们建议1）培训 通过指导研究经验培养下一代临床和转化研究人员， 方法和技能发展，以及量身定制的体验式学习机会; 2）发展参与，多样化 具有可持续的翻译研究事业的初级研究人员;以及3）促进翻译 通过创新的培训策略，在整个生命周期内改善健康结果的学术研究。 第九百一十六页

Contact PD/PI: Heubi, James E Inst-Career-Dev-001 (001) I. INSTITUTIONAL CAREER DEVELOPMENT CORE (KL2 PROGRAM) ABSTRACT The University of Cincinnati Center for Clinical and Translational Science and Training (CCTST) has an excellent record of accomplishment in training KL2 Scholars. The KL2 program has appointed 24 Scholars (50% women, 12.5% underrepresented) from diverse disciplines since 2009 (2 per year, for 2- to 3-year appointments). Scholars have published a total of 674 manuscripts and presented 792 abstracts and workshops at national and international scientific meetings. Of the 20 graduates, 95% are still conducting Clinical and Translational Research (CTR) and 100% have served as Principal Investigator (PI) or Co- Investigator (Co-I) of an externally-funded CTR grant: 20% have transitioned to PI of a career development award (CDA), 65% to PI of a federal independent grant, 75% to PI of a CDA or federal independent grant, and 95% to PI or Co-I of a federal independent grant. Graduates have served as PI of 7 R01s, 3 independent Department of Defense grants, 4 R21s, 1 R03, 2 R40s, 1 R25, 1 R15, 1 U19, 2 K23s, 1 K25, and 1 American Heart Association CDA. They have served as site PI of 3 U01s. The sum of direct costs generated by Scholars’ grants is $109,286,934. Our team has increasingly appreciated the need to address the challenges to developing junior researchers, including: 1) recruiting and developing diverse investigators; 2) training them to be competent in a broad spectrum of core CTR skills; 3) preparing them to successfully conduct team science; 4) ensuring that they achieve sustainable and independent careers; 5) fostering vitality (professionally engaged, committed, and fulfilled) despite increasing levels of burnout among academic faculty; and 6) encouraging them to integrate stakeholder priorities in research and disseminate research to improve health outcomes. As a result, we have designed our KL2 Scholars program to address these challenges using evidence-based strategies, to achieve the following Specific Aims: 1) Train the next generation of clinical and translational investigators through mentored research experiences, core methods and skills development, and tailored experiential learning opportunities; 2) Develop engaged, diverse junior investigators who have sustainable translational research careers; and 3) Promote the translation of Scholar research into improved health outcomes across the lifespan. We have planned several new collaborations across CTSA hubs and a number of innovations that can be scaled up to include other hubs, using the 3D (develop, demonstrate and disseminate) approach. We have designed a rigorous program evaluation plan including NCATS common metrics, have incorporated broad training in research ethics, and have developed a comprehensive plan to increase the recruitment and retention of investigators who are underrepresented in biomedical research. Success will be measured by the following outcomes: 1) we recruit diverse, vibrant Scholars, 2) Scholars secure grants and publish work in high-impact journals; 3) Scholars develop sustained, independent research careers; and 4) Scholars’ research results in improved health outcomes. Commonly-Used Abbreviations: AHC – Academic Health Center; BERD – Biostatistics, Epidemiology, and Research Design; CCHMC – Cincinnati Children’s Hospital Medical Center; CCTST – Center for Clinical and Translational Science and Training; CDA – Career Development Award; CIS – Center for Improvement Science; CTR – Clinical and Translational Research; IDP – Individual Development Plan; OAACD – Office of Academic Affairs and Career Development; PTC – Pilot Translational and Clinical Studies Core; TWD – Translational Workforce Development; UCCOM – University of Cincinnati College of Medicine; URM – Underrepresented Minority Page 915 Project Summary/Abstract Contact PD/PI: Heubi, James E Inst-Career-Dev-001 (001) Narrative The NCATS KL2 career development programs are foundational to developing the next generation of clinical and translational researchers and ensuring that they achieve career success and research independence. The University of Cincinnati Center for Clinical and Translational Science and Training has a strong record of accomplishment in training KL2 Scholars: of the 20 graduates, 95% are still conducting clinical and translational research, 100% have served as Principal Investigator or Co-Investigator of an externally-funded grant, and the sum of direct costs generated by Scholars’ grants I $109,286,934. We propose to 1) train the next generation of clinical and translational investigators through mentored research experiences, core methods and skills development, and tailored experiential learning opportunities; 2) develop engaged, diverse junior investigators who have sustainable translational research careers; and 3) promote the translation of Scholar research into improved health outcomes across the lifespan, through innovative training strategies. Page 916