Exploring the molecular basis of ligand-directed activity in G protein-coupled receptor signalling diversity using the beta adrenergic and muscarinic acetylcholine receptors as models.

使用 β 肾上腺素能和毒蕈碱乙酰胆碱受体作为模型，探索 G 蛋白偶联受体信号多样性中配体定向活性的分子基础。

• 批准号: nhmrc : 1013819
• 负责人: Dr Emma Van Der Westhuizen
• 金额: $ 24.74万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-molecular-basis-receptors-models/109753
• 关键词: Exploring; molecular; basis; ligand; directed

Dysfunction of cell surface receptors is the underlying cause of many pathological conditions. Using cell based screening methods we aim to investigate the mechanisms underlying drug action, to understand how drugs acting at common targets promote distinct biological responses. This will aid the development of new therapeutics based on the ability to predict specific drug effects.

细胞表面受体的功能障碍是许多病理状况的根本原因。利用基于细胞的筛选方法，我们旨在研究药物作用的机制，了解药物如何作用于共同的靶点，促进不同的生物反应。这将有助于基于预测特定药物作用能力的新疗法的发展。