Self-Gated Cardiac MRI

说明(申请人提供)：心血管疾病(CVD)是导致男性和女性死亡的主要原因。磁共振成像(MRI)是一种非常有前途的检测和表征脑血管病的成像手段。临床广泛应用的主要MRI检查之一是心血管形态和运动的动态(电影)成像，用于评估心脏功能。成功的心脏磁共振成像的一个主要要求是通过在数据采集过程中补偿心脏的运动来减少潜在的图像伪影。这通常是通过心电门控和屏气来实现的。MR扫描仪中的心电门控对心律失常并不总是可靠或足够敏感。屏气并不适用于所有患者，并且限制了图像采集时间，因此限制了时间和空间分辨率以及整体图像质量。该项目的目标是通过提供更强大的心脏周期同步策略和消除屏气来改进心脏MRI。这将使用自选通策略来完成，该策略从成像数据本身提取运动信息。这可能会潜在地允许患者进行心脏磁共振成像，而这是传统技术所不能实现的。这些项目的具体目标是验证以下假设：具体目标1：自门控可用于将MR电影成像数据与心脏周期进行稳健的回溯同步，同时改善了心电门控的心律失常排斥能力。具体目标2：自门控可用于将图像采集与呼吸周期同步，从而允许在自由呼吸时进行分段MRI。具体目的3：自门控可用于自由呼吸的高分辨率3D全心电影磁共振成像。具体目的4：自选通法可用于预期将MR图像采集同步到心脏周期的舒张期。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death in both men arid women. Magnetic resonance imaging (MRI) is a highly promising imaging modality for the detection and characterization of CVD. 1 of the major MRI tests that has found widespread clinical application is the dynamic (cine) imaging of cardiovascular morphology and motion for assessment of cardiac function. A major requirement for successful cardiac MRI is to reduce potential image artifacts by compensating the motion of the heart during data acquisition. This has usually been accomplished by electrocardiogram (ECG) gating and breath-holding. ECG gating within the MR scanner is not always reliable or sufficiently sensitive to arrhythmias. Breath-holding is not feasible in all patients and limits image acquisition time therefore limiting temporal and spatial resolution as well as overall image quality. The objective of the project is to improve cardiac MRI by providing more robust cardiac cycle synchronization strategies and eliminating breath-holding. This will be accomplished using self-gating strategies which extract motion information from the imaging data itself. This may potentially allow for cardiac MR imaging in patients that is not feasible using conventional techniques. The specific aims of the projects are to validate the following hypotheses: Specific Aim 1: Self-gating can be used for robust retrospective synchronization of MR cine imaging data to the cardiac cycle with improved arrhythmia rejection capabilities over ECG gatirig. Specific Aim 2: Self-gating can be used for synchronization of image acquisition to the respiratory cycle allowing segmented cine MRI while free-breathing. Specific Aim 3: Self-gating can be used for free-breathing high resolution 3D whole heart cine MRI. Specific Aim 4: Self-gating can be used for prospective synchronization of MR image acquisition to the diastolic phase of the cardiac cycle.