Prenatal Determinants of Schizophrenia, II

精神分裂症的产前决定因素，II

• 批准号: 6928374
• 负责人: CATHERINE Ann SCHAEFER
• 金额: $ 55.78万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-28 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928374
• 关键词: clinical research; disease /disorder etiology; early experience; embryo /fetus toxicology; gene environment interaction; human data; human middle age (35-64); human subject; influenza; labor complications; longitudinal human study; mental health epidemiology; patient oriented research; pregnancy infection; prenatal stress; schizophrenia

DESCRIPTION (provided by applicant): This study will investigate the role of prenatal determinants of schizophrenia and schizophrenia spectrum disorder (SSD) by following-up a cohort of 19,000 individuals born in 1959-1967 in Alameda County, CA. The study builds upon and extends two prior investigations: The Child Health and Development Study, which collected extensive data on over 20,000 pregnancies in a representative cohort of women belonging to Kaiser Foundation Health Plan (KFHP) in Oakland, CA; and the Prenatal Determinants of Schizophrenia (PDS) Study, which used KFHP membership records and psychiatric treatment registries to ascertain and diagnose 71 cases of SSD among the adolescent/adult offspring from the CHDS. The membership and treatment registries of KFHP, as well as electronic records of state residence and county mental health services, will be used to ascertain and diagnose additional SSD cases from the same cohort, resulting in a sample of over 180 SSD cases for study. Using a nested case-control design, matched controls will be selected from the population at risk for each case. The study will also obtain family history of SSD for cases and a matched sample of controls, and obtain blood from cases and controls for later genetic studies. Stored maternal serum samples from the index pregnancies will be assayed for infectious and immunologic exposures. Using statistical methods appropriate to the nested case-control design, the study will then proceed to replicate findings from the prior PDS study (e.g., maternal influenza infection in early pregnancy significantly increases risk of SSD in offspring); examine other potential determinants of SSD (e.g., prenatal exposure to maternal amphetamine use); and investigate the potential causal pathways between prenatal factors and risk of SSD. The study will hypothesize relationships among factors associated with SSD, including family history of schizophrenia, maternal and paternal factors, and prenatal exposures, then systematically analyze and describe the pathways among factors that predict SSD.

描述（由申请人提供）：本研究将调查精神分裂症和精神分裂症谱系障碍（SSD）的产前决定因素的作用，通过对1959-1967年出生在加利福尼亚州阿拉米达县的19,000人进行随访。该研究建立并扩展了先前的两项调查：儿童健康与发展研究，该研究收集了加利福尼亚州奥克兰凯撒基金会健康计划（KFHP）中具有代表性的妇女队列中超过20,000例怀孕的大量数据；精神分裂症的产前决定因素研究（PDS），该研究使用KFHP成员记录和精神病学治疗登记来确定和诊断71例CHDS的青少年/成年后代中的SSD。将利用KFHP的成员和治疗登记，以及国家住所和县精神卫生服务的电子记录，确定和诊断来自同一队列的其他SSD病例，从而获得180多例SSD病例的样本进行研究。使用嵌套病例-对照设计，将从每个病例的高危人群中选择匹配的对照。该研究还将获取病例和对照组匹配样本的SSD家族史，并获取病例和对照组的血液，用于以后的遗传研究。将对储存的首次妊娠的母体血清样本进行感染和免疫暴露检测。使用适用于巢式病例对照设计的统计方法，该研究将继续重复先前PDS研究的发现（例如，妊娠早期母亲感染流感显著增加后代患SSD的风险）；检查SSD的其他潜在决定因素（例如，产前暴露于母体使用安非他明）；并探讨产前因素与SSD风险之间的潜在因果关系。本研究将假设与SSD相关的因素之间的关系，包括精神分裂症家族史、父母因素和产前暴露，然后系统地分析和描述预测SSD的因素之间的途径。