Prenatal Determinants of Schizophrenia, II

精神分裂症的产前决定因素，II

• 批准号: 7500084
• 负责人: CATHERINE Ann SCHAEFER
• 金额: $ 51.8万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-28 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7500084
• 关键词: Address; Adolescent; Adult; Adult Children; Affect; Amphetamines; Barbiturates; Biological Assay; Birth; Blood; Body mass index; Candidate Disease Gene; Case Study; Characteristics; Child; Child Development; Child health care; Cohort Studies; County; Cytomegalovirus; Data; Delusional disorder; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Discipline of obstetrics; Disease; Diuretics; Doctor of Philosophy; Electronics; Exposure to; Family history of; Fatigue; Foundations; Genetic; Genotype; Gestational Diabetes; Health Planning; Herpes Simplex Infections; Hypertension; Hypertension induced by pregnancy; Immunologics; Individual; Influenza; Investigation; Left; Life; Link; Low Prevalence; Mental Health Services; Negative Finding; Numbers; Other Finding; Other Resources; Paternal Age; Pathway interactions; Populations at Risk; Pre-Eclampsia; Pregnancy; Pregnant Women; Psychiatric therapeutic procedure; Recording of previous events; Records; Registries; Reproducibility; Research Design; Research Personnel; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Schizophrenia; Schizotypal Personality Disorder; Serological; Severities; Source; Specimen; Statistical Methods; Testing; Time; Toxicant exposure; Weight maintenance regimen; Woman; affective psychoses; barbituric acid salt; case control; cohort; cytokine; design; follow-up; gene environment interaction; indexing; interest; maternal serum; member; prenatal; prenatal exposure; prenatal risk factor; programs; residence

DESCRIPTION (provided by applicant): This study will investigate the role of prenatal determinants of schizophrenia and schizophrenia spectrum disorder (SSD) by following-up a cohort of 19,000 individuals born in 1959-1967 in Alameda County, CA. The study builds upon and extends two prior investigations: The Child Health and Development Study, which collected extensive data on over 20,000 pregnancies in a representative cohort of women belonging to Kaiser Foundation Health Plan (KFHP) in Oakland, CA; and the Prenatal Determinants of Schizophrenia (PDS) Study, which used KFHP membership records and psychiatric treatment registries to ascertain and diagnose 71 cases of SSD among the adolescent/adult offspring from the CHDS. The membership and treatment registries of KFHP, as well as electronic records of state residence and county mental health services, will be used to ascertain and diagnose additional SSD cases from the same cohort, resulting in a sample of over 180 SSD cases for study. Using a nested case-control design, matched controls will be selected from the population at risk for each case. The study will also obtain family history of SSD for cases and a matched sample of controls, and obtain blood from cases and controls for later genetic studies. Stored maternal serum samples from the index pregnancies will be assayed for infectious and immunologic exposures. Using statistical methods appropriate to the nested case-control design, the study will then proceed to replicate findings from the prior PDS study (e.g., maternal influenza infection in early pregnancy significantly increases risk of SSD in offspring); examine other potential determinants of SSD (e.g., prenatal exposure to maternal amphetamine use); and investigate the potential causal pathways between prenatal factors and risk of SSD. The study will hypothesize relationships among factors associated with SSD, including family history of schizophrenia, maternal and paternal factors, and prenatal exposures, then systematically analyze and describe the pathways among factors that predict SSD.

描述（由申请人提供）：本研究将通过对 1959-1967 年出生于加利福尼亚州阿拉米达县的 19,000 名个体进行随访，调查精神分裂症和精神分裂症谱系障碍 (SSD) 的产前决定因素的作用。 该研究以之前的两项调查为基础并进行了扩展：儿童健康与发展研究，该研究收集了来自加州奥克兰凯撒基金会健康计划 (KFHP) 的代表性妇女群体中超过 20,000 例怀孕的大量数据；精神分裂症产前决定因素 (PDS) 研究，利用 KFHP 会员记录和精神科治疗登记来确定和诊断 CHDS 青少年/成年后代中的 71 例 SSD。 KFHP 的会员资格和治疗登记，以及州居住和县精神卫生服务的电子记录，将用于确定和诊断同一队列中的其他 SSD 病例，从而获得 180 多个 SSD 病例的样本进行研究。使用嵌套病例对照设计，将从每个病例的危险人群中选择匹配的对照。该研究还将获得病例的 SSD 家族史和匹配的对照样本，并从病例和对照中获取血液用于后续的基因研究。将从指示妊娠中储存的母体血清样本进行感染性和免疫性暴露分析。使用适合巢式病例对照设计的统计方法，该研究将继续复制先前 PDS 研究的结果（例如，孕早期母亲感染流感会显着增加后代患 SSD 的风险）；检查 SSD 的其他潜在决定因素（例如，产前接触母亲使用安非他明）；并探讨产前因素与 SSD 风险之间的潜在因果关系。该研究将假设与SSD相关的因素之间的关系，包括精神分裂症家族史、母亲和父亲因素以及产前暴露，然后系统地分析和描述预测SSD的因素之间的路径。