Prenatal Determinants of Schizophrenia, II

精神分裂症的产前决定因素，II

• 批准号: 7678383
• 负责人: CATHERINE Ann SCHAEFER
• 金额: $ 52.12万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-28 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678383
• 关键词: Address; Adolescent; Adult; Adult Children; Affect; Amphetamines; Barbiturates; Biological Assay; Birth; Blood; Body mass index; Candidate Disease Gene; Case Study; Characteristics; Child; Child Development; Child health care; Cohort Studies; County; Cytomegalovirus; Data; Delusional disorder; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Discipline of obstetrics; Disease; Diuretics; Doctor of Philosophy; Electronics; Exposure to; Family history of; Fatigue; Foundations; Genetic; Genotype; Gestational Diabetes; Health Planning; Herpes Simplex Infections; Hypertension; Hypertension induced by pregnancy; Immunologics; Individual; Influenza; Investigation; Left; Life; Link; Low Prevalence; Mental Health Services; Negative Finding; Paternal Age; Pathway interactions; Populations at Risk; Pre-Eclampsia; Pregnancy; Pregnant Women; Psychiatric therapeutic procedure; Recording of previous events; Records; Registries; Reproducibility; Research Design; Research Personnel; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Schizophrenia; Schizotypal Personality Disorder; Serological; Severities; Source; Specimen; Statistical Methods; Testing; Time; Toxicant exposure; Weight maintenance regimen; Woman; affective psychoses; barbituric acid salt; case control; cohort; cytokine; design; follow-up; gene environment interaction; indexing; interest; maternal serum; member; offspring; prenatal; prenatal exposure; prenatal risk factor; programs; residence

DESCRIPTION (provided by applicant): This study will investigate the role of prenatal determinants of schizophrenia and schizophrenia spectrum disorder (SSD) by following-up a cohort of 19,000 individuals born in 1959-1967 in Alameda County, CA. The study builds upon and extends two prior investigations: The Child Health and Development Study, which collected extensive data on over 20,000 pregnancies in a representative cohort of women belonging to Kaiser Foundation Health Plan (KFHP) in Oakland, CA; and the Prenatal Determinants of Schizophrenia (PDS) Study, which used KFHP membership records and psychiatric treatment registries to ascertain and diagnose 71 cases of SSD among the adolescent/adult offspring from the CHDS. The membership and treatment registries of KFHP, as well as electronic records of state residence and county mental health services, will be used to ascertain and diagnose additional SSD cases from the same cohort, resulting in a sample of over 180 SSD cases for study. Using a nested case-control design, matched controls will be selected from the population at risk for each case. The study will also obtain family history of SSD for cases and a matched sample of controls, and obtain blood from cases and controls for later genetic studies. Stored maternal serum samples from the index pregnancies will be assayed for infectious and immunologic exposures. Using statistical methods appropriate to the nested case-control design, the study will then proceed to replicate findings from the prior PDS study (e.g., maternal influenza infection in early pregnancy significantly increases risk of SSD in offspring); examine other potential determinants of SSD (e.g., prenatal exposure to maternal amphetamine use); and investigate the potential causal pathways between prenatal factors and risk of SSD. The study will hypothesize relationships among factors associated with SSD, including family history of schizophrenia, maternal and paternal factors, and prenatal exposures, then systematically analyze and describe the pathways among factors that predict SSD.

描述（由申请人提供）：本研究将通过跟进1959 - 1967年在加利福尼亚州阿拉米达县出生的19,000名个人来研究精神分裂症和精神分裂症谱系障碍（SSD）产前决定因素（SSD）的作用。 该研究基于并扩展了两项先前的研究：儿童健康与发展研究，该研究在加利福尼亚州奥克兰的Kaiser Foundation Health Plan（KFHP）的一组代表妇女中收集了有关20,000多名怀孕的广泛数据；精神分裂症（PDS）研究的产前决定因素（使用KFHP成员资格记录和精神病治疗登记册来确定和诊断来自CHD的青少年/成人后代中的71例SSD病例。 KFHP的会员和治疗登记处以及国家居住和县心理健康服务的电子记录将用于确定和诊断同一同类群体的其他SSD病例，从而导致超过180个SSD案例进行研究。使用嵌套的情况对照设计，将从每个情况下的人群中选择匹配的控件。该研究还将获得有关病例和匹配的对照样本的SSD家族史，并从病例和对照中获取血液以进行后期遗传研究。从指数妊娠中储存的母体血清样品将用于传染性和免疫学暴露。然后，使用适合嵌套病例对照设计的统计方法，该研究将继续复制先前的PDS研究中的发现（例如，妊娠早期的母体流感感染可显着增加后代SSD的风险）；检查SSD的其他潜在决定因素（例如，产前暴露于母体苯丙胺的使用）；并研究产前因素和SSD风险之间的潜在因果途径。该研究将假设与SSD相关的因素之间的关系，包括精神分裂症的家族史，母亲和父亲因素以及产前暴露，然后系统地分析和描述预测SSD的因素之间的途径。