Sensory Processing Deficits in Cannabis Use

大麻使用中的感官处理缺陷

• 批准号: 7037727
• 负责人: PATRICK David SKOSNIK
• 金额: $ 7.58万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7037727
• 关键词: auditory stimulus; behavioral /social science research tag; clinical research; drug detection; electroencephalography; evoked potentials; human subject; interview; marijuana abuse; neural information processing; perceptual distortions; personality; psychometrics; psychopharmacology; questionnaires; substance abuse related behavior; visual stimulus

DESCRIPTION (provided by applicant): It is well known that use of the drug cannabis can induce subjective distortions of perception in several sensory modalities. However, few direct examinations of the neural effects of cannabis use on early sensory processing have been undertaken, particularly utilizing novel electrophysiological techniques. The overall aim of the current proposal is to examine whether current cannabis users demonstrate deficits in neural synchronization as measured by electroencephalographic (EEG) entrainment to periodic auditory and visual stimulation. Subjects will passively observe periodic sensory stimuli (auditory click-trains (10, 20, 30, 40, and 50 Hz) and photic flickers (8, 13, 18, 25, and 38 Hz) while EEGs are recorded. The ability of the resulting steady-state potentials to synchronize to the specific frequencies of stimulation will be assessed via EEG power, signal to noise ratio, and intertrial coherence. In addition, EEG synchronization during perceptual binding will be assessed utilizing an induced gamma paradigm (moving dot stimuli using Random Dot Kinetograms). Several clinical interviews and psychometric questionnaires will also be administered in order to determine possible relationships between EEG brain measures and the perceptual correlates of cannabis use. It is hypothesized that during the entrainment paradigms cannabis users will exhibit decreased EEG power, signal to noise ratio, and intertrial coherence at the frequencies of stimulation across sensory modalities. It is also predicted that during the induced EEG paradigm, cannabis users will exhibit decreased gamma-band (~ 40 Hz) activity during the perception of coherent moving dots. It is hypothesized that these deficits in EEG neural synchronization will correlate with psychometric measures such as schizotypal personality and perceptual aberration, as well as urinary measures of cannabis metabolites. Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization.

描述（由申请人提供）：众所周知，大麻药物的使用会引起几种感觉方式的主观感知扭曲。然而，很少直接检查大麻使用对早期感觉处理的神经影响，特别是利用新的电生理技术。当前提案的总体目标是检查当前大麻使用者是否表现出神经同步的缺陷，如通过脑电图（EEG）对周期性听觉和视觉刺激的夹带所测量的。受试者将被动地观察周期性感觉刺激（听觉点击序列（10、20、30、40和50 Hz）和光闪烁（8、13、18、25和38 Hz），同时记录EEG。将通过EEG功率、信噪比和试验间相干性评估所得稳态电位与特定刺激频率同步的能力。此外，将利用诱导伽马范例（使用随机点运动图的移动点刺激）评估感知绑定期间的EEG同步。还将进行几次临床访谈和心理测量问卷调查，以确定脑电图大脑测量与大麻使用的感知相关性之间可能存在的关系。据推测，在夹带范式大麻用户将表现出降低EEG功率，信噪比，和试验间的连贯性在整个感官模式的刺激频率。据预测，在诱导EEG范例期间，大麻使用者在感知相干移动点期间将表现出减少的伽马波段（~ 40 Hz）活动。据推测，这些缺陷在EEG神经同步将与心理测量的措施，如典型的个性和知觉畸变，以及大麻代谢产物的尿液措施。两者合计，这些数据可能有助于阐明在大麻使用中观察到的已知认知功能障碍是否部分与早期感觉信息处理和/或神经同步的干扰有关。