Amphetamine Sensitization and Prefrontal Cortex Function
Amphetamine Sensitization and Prefrontal Cortex Function
批准号:
6955694
负责人:
Joshua M Gulley
金额:
$7.65万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-08-16 至 2007-08-31
关键词:
amphetaminesbehavior testbehavioral /social science research tagbehavioral habituation /sensitizationdrug addictionelectrophysiologylaboratory ratneural conductionneural plasticityneuronsneurophysiologynucleus accumbensopen field behaviorprefrontal lobe /cortexsingle cell analysissubstance abuse related behaviortegmentum
中文摘要
描述(由申请人提供):
英文摘要
DESCRIPTION (provided by applicant):
Repeated exposure to psychostimulant drugs such as amphetamine (AMPH) often leads to behavioral sensitization, which refers to enhanced motor responsiveness to subsequent drug administration. Alterations in brain anatomy and function parallel behavior changes and these adaptations have been hypothesized to contribute to the development and maintenance of human drug addiction. A large body of studies, mostly performed in rats, has implicated dopamine- and glutamate-containing brain areas within cortico-limbic and striatal pathways as important anatomical substrates for AMPH-induced behavioral sensitization. In particular, the medial prefrontal cortex (mPFC) appears to play an important role in the induction and expression of behavioral sensitization through its influence on the ventral tegmental area and nucleus accumbens, respectively. Thus, studies of mPFC function in awake, behaving subjects are necessary to verify if drug-induced plasticity in the mPFC is important for behavioral sensitization and if changes in neuronal responses correlate to its induction and/or expression. In the experiments proposed here, we will test the following hypotheses: (1) AMPH has acute effects on mPFC neurons that depend on the neuron's responsiveness during behavior and/or to a particular environmental context, and (2) Behavioral sensitization to repeated, intermittent administration of AMPH is correlated with changes in the firing rate and/or pattern of mPFC neurons and this relationship will differ in non-sensitized animals. We will use chronically implanted, multiwire electrodes to record single-neuron activity in the mPFC of rats that are allowed unrestricted movement in an open-field arena. Recordings will be obtained during baseline conditions, after saline administration, and after rats have undergone either acute or chronic treatment with AMPH. Ultimately, these experiments will help clarify the role of mPFC plasticity in behavioral sensitization and will further our understanding of the neuroadaptations associated with repeated drug intake.
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会议论文
Neural mechanisms of sex differences in vulnerability to the effects of adolescent methamphetamine exposure
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批准号:10527234
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项目类别:
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资助金额:$21.9万
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财政年份:2022
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负责人:Joshua M Gulley
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依托单位:
Neural mechanisms of sex differences in vulnerability to the effects of adolescent methamphetamine exposure
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批准号:10669275
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Mechanisms of metabolic and cognitive dysregulation after combined alcohol and THC use
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批准号:9788404
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资助金额:$16.8万
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财政年份:2018
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Mechanisms of amphetamine-induced plasticity in adolescents compared to adults
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批准号:8796174
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资助金额:$30.01万
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财政年份:2011
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负责人:Joshua M Gulley
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Mechanisms of amphetamine-induced plasticity in adolescents compared to adults
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批准号:8217063
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资助金额:$29.72万
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财政年份:2011
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负责人:Joshua M Gulley
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依托单位:
Mechanisms of amphetamine-induced plasticity in adolescents compared to adults
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批准号:8603853
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项目类别:
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资助金额:$30.5万
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财政年份:2011
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负责人:Joshua M Gulley
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Mechanisms of amphetamine-induced plasticity in adolescents compared to adults
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批准号:8416995
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资助金额:$29.31万
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财政年份:2011
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负责人:Joshua M Gulley
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依托单位:
Mechanisms of amphetamine-induced plasticity in adolescents compared to adults
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批准号:8050315
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项目类别:
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资助金额:$28.73万
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财政年份:2011
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负责人:Joshua M Gulley
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依托单位:
Alcohol drinking behavior and prefrontal cortex neuron loss during adolescence
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批准号:7503401
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项目类别:
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资助金额:$17.19万
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财政年份:2007
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负责人:Joshua M Gulley
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依托单位:
Alcohol drinking behavior and prefrontal cortex neuron loss during adolescence
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批准号:7408976
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项目类别:
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资助金额:$19.76万
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财政年份:2007
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负责人:Joshua M Gulley
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依托单位:
Amphetamine Sensitization: Role of Dopamine Transporters
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批准号:6649551
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项目类别:
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资助金额:$4.81万
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财政年份:2003
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负责人:Joshua M Gulley
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依托单位:
AMPHETAMINE INDUCED CHANGES IN BASAL GANGLIA OUTPUT
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批准号:2775969
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项目类别:
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资助金额:$1.92万
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财政年份:1999
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负责人:Joshua M Gulley
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依托单位:
AMPHETAMINE INDUCED CHANGES IN BASAL GANGLIA OUTPUT
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批准号:2897801
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项目类别:
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资助金额:$1.97万
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财政年份:1999
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负责人:Joshua M Gulley
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依托单位:
海外基金