课题基金 / 基金详情

Circadian Genes and Breast Cancer

Circadian Genes and Breast Cancer
昼夜节律基因与乳腺癌
批准号:
6946515
负责人:
YONG ZHU
金额:
$8.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2004
资助国家:
美国
项目状态:
已结题
起止时间:
2004-09-03 至 2007-08-31

项目摘要

项目成果

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): Emerging data have demonstrated that circadian genes are involved in regulating cell proliferation and apoptosis by controlling expression of tumor suppressor genes, cell cycle genes, as well as genes that encode the caspases and transcription factors. Therefore, as the molecular clockworks regulate many biological pathways in tumorigenesis, mutations in circadian genes could conceivably result in deregulation of these processes and tumour development. In this proposal, we hypothesize that adverse genotypes associated with these circadian genes may modulate their protein functions in biology rhythms, thereby influencing an individual's susceptibility to human cancer. Our specific aims are: 1) To identify single nucleotide polymorphisms (SNPs) with potential functional impact on circadian genes. SNPs will be collected from public SNP databases and screened by different bioinformatic tools. Prediction about functional impact will be made to both SNPs that alter an amino acid and SNPs located in the exonic splicing sites. 2) To determine the role that specific polymorphisms in these genes play in the modulation of breast cancer risk. Our hypothesis is that SNPs predicted to have functional significance in circadian genes may be a novel panel of biomarkers to be associated with breast cancer risk. 3) To investigate the joint-effect between circadian genes and environmental factors, especially night exposure to light. Light is the most powerful circadian synchronizer among all environmental cues. Our hypothesis is that exposure to light at night may disturb circadian rhythms and consequently increase the risk of breast cancer for individuals with the putative high-risk genotypes in circadian genes. Given the availability of DNA samples and exposure data, this proposal is both time and cost effective in terms of practical feasibility.
期刊论文(11)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1186/1471-2407-10-110
发表时间: 2010-03-24
期刊: BMC cancer
影响因子: 3.8
作者: [Hoffman AE, Zheng T, Ba Y, Stevens RG, Yi CH, Leaderer D, Zhu Y]
通讯作者: Zhu Y
DOI: 10.1007/s10549-009-0484-0
发表时间: 2010-04
期刊: BREAST CANCER RESEARCH AND TREATMENT
影响因子: 3.8
作者: [Yi, Chunhui, Mu, Lina, de la Longrais, Irene A. Rigault, Sochirca, Olga, Arisio, Riccardo, Yu, Herbert, Hoffman, Aaron E., Zhu, Yong, Katsaro, Dionyssios]
通讯作者: Katsaro, Dionyssios
DOI: 10.1016/j.canlet.2009.04.017
发表时间: 2009-11-01
期刊: CANCER LETTERS
影响因子: 9.7
作者: [Yi, Chun-Hui, Zheng, Tongzhang, Leaderer, Derek, Hoffman, Aaron, Zhu, Yong]
通讯作者: Zhu, Yong
DOI: 10.1158/0008-5472.can-09-0236
发表时间: 2009-07-15
期刊: Cancer research
影响因子: 11.2
作者: [Hoffman AE, Zheng T, Yi C, Leaderer D, Weidhaas J, Slack F, Zhang Y, Paranjape T, Zhu Y]
通讯作者: Zhu Y
11
    Molecular epidemiology/functional analysis of microRNAs in Non-Hodgkin's lymphoma
    • 批准号:
      8106946
    • 项目类别:
    • 资助金额:
      $34.34万
    • 财政年份:
      2011
    • 负责人:
      YONG ZHU
    • 依托单位:
    Molecular epidemiology/functional analysis of microRNAs in Non-Hodgkin's lymphoma
    • 批准号:
      8234052
    • 项目类别:
    • 资助金额:
      $34.41万
    • 财政年份:
      2011
    • 负责人:
      YONG ZHU
    • 依托单位:
    Molecular epidemiology/functional analysis of microRNAs in Non-Hodgkin's lymphoma
    • 批准号:
      8448743
    • 项目类别:
    • 资助金额:
      $32.44万
    • 财政年份:
      2011
    • 负责人:
      YONG ZHU
    • 依托单位:
    Molecular epidemiology/functional analysis of microRNAs in Non-Hodgkin's lymphoma
    • 批准号:
      8618866
    • 项目类别:
    • 资助金额:
      $33.51万
    • 财政年份:
      2011
    • 负责人:
      YONG ZHU
    • 依托单位:
    国内基金
    海外基金
    基于DNA甲基化交互网络的癌症hallmark挖掘及其在癌症转移biomarker筛选中的应用
    • 批准号:
      61602201
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      20.0万元
    • 批准年份:
      2016
    • 负责人:
      周雄辉
    • 依托单位:
    血清miRNAs成为一种新的biomarker在PD诊断中的价值和LRRK2基因调控的机制研究
    • 批准号:
      81170309
    • 项目类别:
      面上项目
    • 资助金额:
      50.0万元
    • 批准年份:
      2011
    • 负责人:
      颜桥
    • 依托单位:
    生物标志物NGAL和KIM-1分子在急性肾损伤中的作用机制研究及标志物联合检测对早期诊断AKI的作用
    • 批准号:
      81101308
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      22.0万元
    • 批准年份:
      2011
    • 负责人:
      李海霞
    • 依托单位:
    精神分裂症记忆障碍的脑网络组学研究
    • 批准号:
      91132301
    • 项目类别:
      重大研究计划
    • 资助金额:
      350.0万元
    • 批准年份:
      2011
    • 负责人:
      蒋田仔
    • 依托单位: