Identification of the transcriptional drivers of dormancy in luminal breast cancer

腔内乳腺癌休眠转录驱动因素的鉴定

• 批准号: 2476051
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2476051
• 关键词: Identification; transcriptional; drivers; dormancy; luminal

Patients diagnosed with ERa positive breast cancer receive adjuvant hormone therapy, however twenty years post-surgery, up to 50% of women will have relapsed. This demonstrates how therapy succeeds in delaying relapse but fails to eradicate the disease. I will investigate the mechanisms behind treatment-induced cancer cell dormancy and how this leads to resistance to endocrine therapy. To achieve this, I am designing quantitative models using fluorescence microscopy and will eventually interrogate them via CRISPR perturbation screens to capture transcriptional and epigenetic dependencies of dormant cells.

被诊断为ER α阳性乳腺癌的患者接受辅助激素治疗，但手术后20年，高达50%的女性会复发。这表明治疗如何成功地延迟复发，但未能根除疾病。我将研究治疗诱导的癌细胞休眠背后的机制，以及这如何导致对内分泌治疗的抵抗。为了实现这一目标，我正在使用荧光显微镜设计定量模型，并最终通过CRISPR微扰筛选来询问它们，以捕获休眠细胞的转录和表观遗传依赖性。