Parkinsons disease:Visual dysfunction and hallucinations

帕金森病：视觉功能障碍和幻觉

基本信息

批准号：
6919858
负责人：
SUZANNE HOLROYD
金额：
$ 32.6万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-15 至 2008-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The purpose of this three year grant is to examine the relationship between visual hallucinations and visual system abnormality in Parkinson's disease. Visual hallucinations are common symptoms and frequent causes of morbidity in Parkinson's disease, yet little is known about their etiology. Increasing evidence suggests that hallucinations in Parkinson's disease are not simply a medication effect, but are associated with the underlying disease process. Specificallly, evidence exists that suggest visual hallucinations in Parkinson's disease may be related to known visual system dysfunction in Parkinson's disease. In this study, thirty Parkinson's disease patients with visual hallucinations will be matched to thirty Parkinson's disease patients without visual hallucinations. They will be examined on neuropsychological tests assessing visual cognitive function, and will undergo visual evoked potentials. A subset of these patients (20 matched pairs) will also undergo functional magnetic resonance imaging (fMRI) to assess visual cortex function. It is hypothesized that Parkinson's disease patients with visual hallucinations will have greater evidence of visual system abnormality. Specifically they will demonstrate greater deficits of visual-cognitive function, greater latency on visual evoked potential and differences in activation of visual cortical regions on functional magnetic resonance imaging (fMRI) than those without visual hallucinations. It is hypothesized that these results will support a proposed biologic model of VH in PD regarding the role of dopamine abnormality in both the retina and basal ganglia that effect the regulation of function of visual cortex. The results of this study will increase knowledge regarding the neural mechanisms of visual hallucinations in Parkinson's disease and knowledge of visual system abnormality in Parkinson's disease. The results may also increase our understanding of visual hallucinations in other disorders. Conceivably, such knowledge could lead to strategies to prevent, minimize or treat such symptoms.

描述（由申请人提供）：这三年赠款的目的是检查帕金森氏病视觉幻觉与视觉系统异常之间的关系。视觉幻觉是帕金森氏病发病率的常见症状和频繁的原因，但对其病因却一无所知。越来越多的证据表明，帕金森氏病的幻觉不仅是一种药物效应，而且与潜在的疾病过程有关。具体而言，存在表明帕金森氏病视觉幻觉的证据可能与帕金森氏病中已知的视觉系统功能障碍有关。在这项研究中，具有视觉幻觉的三十名帕金森氏病患者将与三十位帕金森氏病患者相匹配而没有视觉幻觉。它们将在评估视觉认知功能的神经心理学测试中进行检查，并将具有视觉诱发电位。这些患者的子集（20对匹配）还将进行功能性磁共振成像（fMRI）来评估视觉皮层功能。假设帕金森氏病视觉幻觉的患者将有更多的视觉系统异常证据。具体而言，与没有视觉幻觉的那些相比，它们将显示出更大的视觉认知功能缺陷，视觉诱发潜力的潜伏期和功能磁共振成像（fMRI）的视觉皮质区域的差异和差异。假设这些结果将支持PD中VH的拟议的生物学模型，该模型在视网膜和基底神经节中的作用，影响视觉皮质功能的调节。这项研究的结果将增加有关帕金森氏病视觉幻觉的神经机制以及帕金森氏病视觉系统异常的知识。结果也可能会增加我们对其他疾病中视觉幻觉的理解。可以想象，这种知识可能导致预防，最小化或治疗此类症状的策略。