Ruthenium-catalysed C-H functionalization of aromatic molecules with anilinium-electrophiles

钌催化苯胺亲电子试剂对芳香族分子进行 C-H 官能化

• 批准号: 2480361
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2480361
• 关键词: Ruthenium; catalysed; functionalization; aromatic; molecules

Objective:This project will investigate the use of anilinium-derived electrophiles as coupling partners for Ru-catalyzed C-H functionalization reactions, and their application to the synthesis or late-stage functionalization of drugs and other biologically active molecules.Approach:A wide variety of anilinium-derived electrophiles will be prepared and tested with a range of Ru-catalysts. Reaction conditions will be optimized, including temperature, solvent, co-additives.Successful classes of electrophiles will be further investigated to map their scope and potential as well as their applications to industrially relevant compounds.Remit:This project falls within the areas of Catalysis and Synthetic Organic Chemistry.

目的：研究苯胺类亲电体偶联剂在Ru催化的C-H功能化反应中的应用，及其在药物和其他生物活性分子的合成或后期功能化中的应用。将优化反应条件，包括温度、溶剂、助剂。将进一步研究成功的亲电性类别，以绘制它们的范围和潜力以及它们在工业相关化合物中的应用。备注：该项目属于催化和合成有机化学领域。