Ruthenium-catalysed C-H functionalization of aromatic molecules with anilinium-electrophiles

目的：研究苯胺类亲电体偶联剂在Ru催化的C-H功能化反应中的应用，及其在药物和其他生物活性分子的合成或后期功能化中的应用。将优化反应条件，包括温度、溶剂、助剂。将进一步研究成功的亲电性类别，以绘制它们的范围和潜力以及它们在工业相关化合物中的应用。备注：该项目属于催化和合成有机化学领域。

Objective:This project will investigate the use of anilinium-derived electrophiles as coupling partners for Ru-catalyzed C-H functionalization reactions, and their application to the synthesis or late-stage functionalization of drugs and other biologically active molecules.Approach:A wide variety of anilinium-derived electrophiles will be prepared and tested with a range of Ru-catalysts. Reaction conditions will be optimized, including temperature, solvent, co-additives.Successful classes of electrophiles will be further investigated to map their scope and potential as well as their applications to industrially relevant compounds.Remit:This project falls within the areas of Catalysis and Synthetic Organic Chemistry.