A randomised trial of zoledronic acid for osteoarthritis of the knee

骨关节炎（OA）是关节炎的最常见形式，并且由于人口老龄化而显著增加。尽管其疾病负担很大，但目前还没有批准的疾病修饰药物可用于改变OA的结构进展。本研究的目的是比较唑来膦酸治疗与安慰剂对膝关节结构变化和膝关节疼痛的影响。据推测，唑来膦酸将减少软骨损失，膝关节疼痛和骨髓病变的大小。

Osteoarthritis (OA) is the most common form of arthritis and is increasing markedly due to an ageing population. Despite its large disease burden, there are currently no approved disease-modifying drugs available which modify structural progression of OA. The aim of this study is to compare zoledronic acid treatment to placebo on knee structural change and knee pain over two years. It is hypothesised that zoledronic acid will reduce cartilage loss, knee pain, and bone marrow lesion size.