Convergent central pathways for sympatho-inhibition

交感神经抑制的汇聚中枢通路

• 批准号: 6839904
• 负责人: CARON DEAN-BERNHOFT
• 金额: $ 12.6万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6839904
• 关键词: brain electronic stimulator; brain mapping; computer data analysis; electroencephalography; electrophysiology; environmental adaptation; environmental stressor; gene environment interaction; hemorrhage; intermolecular interaction; laboratory rat; medulla oblongata; neural information processing; neural inhibition; neural transmission; neurochemistry; neurons; neuropharmacologic agent; neuropharmacology; neuropsychology; neuroregulation; protein structure function; serotonin; serotonin receptor; sympathetic nervous system

DESCRIPTION (provided by applicant): The central nervous system coordinates appropriate behavioral and physiological events in response to imposed environmental challenges but many mechanisms remain to be determined. The present study will focus on a single component which is common to a number of behaviors and conditions to determine whether convergent central pathways exist. Sympatho-inhibition is fundamental to both the recovery phase of a defense response and also to the response to severe hemorrhage. The present proposal is designed to characterize central pathways mediating sympatho-inhibition during these conditions and determine if the sympatho-inhibition is mediated by convergence to a common central pathway. Background and preliminary data suggests that under both conditions sympatho-inhibition is mediated through a final common pathway via 5-HTIA receptors in the sympatho-excitatory region of the rostroventrolateral medulla (RVLM). This would provide a novel serotonergic pathway generating sympatho-inhibition which is distinct from that mediating reflex sympatho-inhibition via GABA receptors on sympatho-excitatory neurons. The proposed studies will extend a finding that a sympatho-inhibition elicited from the ventrolateral periaqueductal gray matter is mediated through activation of 5-HTIA receptors in the RVLM. Sympathetic nerve and central unit recordings combined with microinjection techniques will be utilized to investigate the pathway mediating sympatho-inhibition from the periaqueductal gray via RVLM 5-HTIA receptors, and determine its involvement in the recovery phase of a defense response. Studies will also examine a putative role for activation of 5-HTIA receptors in the RVLM during extreme hemorrhage. The results of these studies will provide insight into the extent of convergence of central pathways mediating sympatho-inhibition during the recovery phase of a defense response and during extreme hemorrhage. The long-term aim of this proposal is to characterize a pathway which may mediate a specific neural response essential to multiple conditions. These novel data will be of potential significance to an array of pathologies and behaviors including emotional behaviors, analgesia, shock, sexual function and fainting.

描述（由申请人提供）：中枢神经系统坐标 响应强加的适当的行为和生理事件 但许多机制仍有待确定。这 本研究将集中于许多共同的单一组成部分 确定是否收敛中央通路的行为和条件 存在。交感抑制对于神经元的恢复阶段至关重要 防御反应以及对严重出血的反应。现在的 提案旨在描述调解的中心途径 在这些情况下交感神经抑制并确定是否 交感神经抑制是通过汇聚到共同的中央通路来介导的。 背景和初步数据表明，在这两种情况下 交感神经抑制是通过 5-HTIA 最终共同途径介导的 延髓头腹外侧交感兴奋区的受体 （RVLM）。这将提供一种新的血清素能途径，产生 交感抑制，与介导反射不同 通过 GABA 受体对交感兴奋神经元的交感抑制。 拟议的研究将扩展交感神经抑制引起的发现 来自腹外侧导水管周围灰质的介导 RVLM 中 5-HTIA 受体的激活。交感神经和中枢单位 记录与显微注射技术相结合将用于 研究导水管周围介导交感神经抑制的途径 通过 RVLM 5-HTIA 受体检测灰色，并确定其参与恢复 防御反应阶段。研究还将检验假定的作用 极度出血期间 RVLM 中 5-HTIA 受体的激活。这 这些研究的结果将提供对趋同程度的深入了解 恢复阶段介导交感神经抑制的中枢通路 防御反应和极度失血期间。 该提案的长期目标是描述一条可能的途径 介导多种条件所必需的特定神经反应。这些 新数据将对一系列病理学具有潜在意义 行为包括情绪行为、镇痛、休克、性功能和 晕倒了。