Convergent central pathways for sympatho-inhibition

描述(申请人提供)：中枢神经系统坐标 适当的行为和生理事件对强加的反应 环境挑战，但许多机制仍有待确定。这个 目前的研究将集中在单个组件上，该组件对于多个 判断汇聚中枢通路是否存在的行为和条件 是存在的。交感神经抑制是脑力衰竭恢复期的基础 防御反应和对严重出血的反应。现在 该提案旨在描述中枢调节通路的特征 在这些情况下的交感抑制，并确定是否 交感神经抑制是通过汇聚到共同的中枢通路来实现的。 背景和初步数据表明，在这两种情况下 交感神经抑制是通过5-HTIA介导的最终共同途径 延髓轮状腹外侧区交感兴奋区的受体 (RVLM)。这将提供一种新的5-羟色胺能途径 不同于中介反射的交感抑制 通过GABA受体对交感兴奋神经元的交感抑制。 拟议中的研究将扩展一项发现，即交感神经抑制会引起 来自中脑导水管周围灰质的腹外侧部通过 激活RVLM中的5-HTIA受体。交感神经和中枢单位 录音与微注射技术相结合将被用于 中脑导水管周围交感神经抑制通路的研究 Gray通过RVLM5-HTIA受体，并确定其在恢复中的作用 防御反应的阶段。研究还将研究假设的作用 严重出血时RVLM中5-HTIA受体的激活。这个 这些研究的结果将使我们深入了解 中枢通路在老年痴呆恢复期交感神经抑制中的作用 防御反应和严重出血时。 这项提议长期目标是描述一条可能 调节对多种情况至关重要的特定神经反应。这些 新的数据将对一系列病理学和 行为包括情绪行为、止痛、休克、性功能和 晕倒了。

DESCRIPTION (provided by applicant): The central nervous system coordinates appropriate behavioral and physiological events in response to imposed environmental challenges but many mechanisms remain to be determined. The present study will focus on a single component which is common to a number of behaviors and conditions to determine whether convergent central pathways exist. Sympatho-inhibition is fundamental to both the recovery phase of a defense response and also to the response to severe hemorrhage. The present proposal is designed to characterize central pathways mediating sympatho-inhibition during these conditions and determine if the sympatho-inhibition is mediated by convergence to a common central pathway. Background and preliminary data suggests that under both conditions sympatho-inhibition is mediated through a final common pathway via 5-HTIA receptors in the sympatho-excitatory region of the rostroventrolateral medulla (RVLM). This would provide a novel serotonergic pathway generating sympatho-inhibition which is distinct from that mediating reflex sympatho-inhibition via GABA receptors on sympatho-excitatory neurons. The proposed studies will extend a finding that a sympatho-inhibition elicited from the ventrolateral periaqueductal gray matter is mediated through activation of 5-HTIA receptors in the RVLM. Sympathetic nerve and central unit recordings combined with microinjection techniques will be utilized to investigate the pathway mediating sympatho-inhibition from the periaqueductal gray via RVLM 5-HTIA receptors, and determine its involvement in the recovery phase of a defense response. Studies will also examine a putative role for activation of 5-HTIA receptors in the RVLM during extreme hemorrhage. The results of these studies will provide insight into the extent of convergence of central pathways mediating sympatho-inhibition during the recovery phase of a defense response and during extreme hemorrhage. The long-term aim of this proposal is to characterize a pathway which may mediate a specific neural response essential to multiple conditions. These novel data will be of potential significance to an array of pathologies and behaviors including emotional behaviors, analgesia, shock, sexual function and fainting.