X-LINKED SEVERE COMBINED IMMUNODEFICIENCY IN THE DOG

X连锁狗的严重联合免疫缺陷病

基本信息

  • 批准号:
    7153989
  • 负责人:
  • 金额:
    $ 0.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-08-01 至 2006-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): It is now possible to isolate genes involved in genetic diseases and understand disease mechanisms in terms of the underlying molecular derangements, and there are encouraging new prospects for therapy for genetic diseases, including gene therapy. The full scope of understanding and treating genetic diseases in human patients cannot be realized without authentic (gene-homologous) animal models for studies not possible for ethical and practical reasons in human patients. Mouse gene knockout technology has provided a valuable source, but additional models are needed for studies requiring long-lived animals of larger size to be able to monitor clinical signs and with phenotypes more closely resembling the human diseases. A large reservoir of such models is present in existing animal populations and can be studied with the cooperation of breeders, veterinarians, and others interested in genetic disease control. The investigators have shown that this resource can be utilized by providing an accessible Center to ascertain, verify, and preserve these models. The objective of this project is to continue to serve as a NRC to identify, characterize, and make available for research, new animal models of human genetic disease. The models sought among laboratory, domesticated, and wild species, including nonhuman primates (NHPs), will involve defects in homologous gene loci having essentially the same molecular and clinical phenotypes as in human patients. Models offering new opportunities to investigate disease pathogenesis and approaches to therapy will be emphasized. The Center will provide the clinical, pathological, and molecular genetic studies required to establish homology with the human disorder. Verified models will be made available in the form of DNA, cells, frozen semen, breeding stock, and, in selected models, normal and mutant cDNAs.
描述(由申请人提供):

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Peter J Felsburg其他文献

Peter J Felsburg的其他文献

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{{ truncateString('Peter J Felsburg', 18)}}的其他基金

Gene Therapy for Canine X-linked SCID
犬 X 连锁 SCID 的基因治疗
  • 批准号:
    8281427
  • 财政年份:
    2011
  • 资助金额:
    $ 0.06万
  • 项目类别:
Gene Therapy for Canine X-linked SCID
犬 X 连锁 SCID 的基因治疗
  • 批准号:
    8259611
  • 财政年份:
    2011
  • 资助金额:
    $ 0.06万
  • 项目类别:
Gene Therapy for Canine X-linked SCID
犬 X 连锁 SCID 的基因治疗
  • 批准号:
    7860328
  • 财政年份:
    2009
  • 资助金额:
    $ 0.06万
  • 项目类别:
Gene Therapy for Canine X-linked SCID
犬 X 连锁 SCID 的基因治疗
  • 批准号:
    7662912
  • 财政年份:
    2009
  • 资助金额:
    $ 0.06万
  • 项目类别:
CLINICAL IMMUNOLOGY LABORATORY
临床免疫学实验室
  • 批准号:
    7391969
  • 财政年份:
    2006
  • 资助金额:
    $ 0.06万
  • 项目类别:
X-LINKED SEVERE COMBINED IMMUNODEFICIENCY IN THE DOG
狗的 X 连锁严重联合免疫缺陷病
  • 批准号:
    7391952
  • 财政年份:
    2006
  • 资助金额:
    $ 0.06万
  • 项目类别:
CLINICAL IMMUNOLOGY LABORATORY
临床免疫学实验室
  • 批准号:
    7154007
  • 财政年份:
    2005
  • 资助金额:
    $ 0.06万
  • 项目类别:
X-LINKED SEVERE COMBINED IMMUNODEFICIENCY IN THE DOG
X连锁狗的严重联合免疫缺陷病
  • 批准号:
    7011847
  • 财政年份:
    2004
  • 资助金额:
    $ 0.06万
  • 项目类别:
CLINICAL IMMUNOLOGY LABORATORY
临床免疫学实验室
  • 批准号:
    7011865
  • 财政年份:
    2004
  • 资助金额:
    $ 0.06万
  • 项目类别:
GENERATION OF XSCID/HU DOGS
XSCID/HU 狗的一代
  • 批准号:
    6576604
  • 财政年份:
    2002
  • 资助金额:
    $ 0.06万
  • 项目类别:
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