Proposal for Central California 900 MHZ NMR Spectrometer

加州中部 900 MHZ 核磁共振波谱仪提案

• 批准号: 6899776
• 负责人: DAVID E WEMMER
• 金额: $ 21.4万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6899776
• 关键词: biomedical equipment resource; biomedical facility; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): A shared 900 MHz NMR facility will be established for the Central California area, to be housed in the new QB3 Institute (Institute for Quantitative Biomedical Research) at the University of California Berkeley. The instrument will be available to investigators throughout the region. Specific proposals are included from investigators at UC Berkeley, Stanford, UC San Francisco, UC Davis, Lawrence Livermore National Lab and Genentech. Time on the instrument will be allocated to maximize its application to problems which challenge the limits of current NMR capability. Systems under study will include large viral and ribosomal RNAs, VS ribozyme, viral protein-RNA interactions, metalloprotein heine oxygenases, TNF ligand and receptor interactions, bacterial transcriptional activators, proteins studied inside cells, cytokines and their receptors, and proteins involved in DNA repair and their complexes. Support for carrying out state of the art spectroscopy, libraries of pulse sequences and their documentation, and general user guides will be provided by staff members in the facility.

描述（由申请人提供）：将为加州中部地区建立一个共享的 900 MHz NMR 设施，位于加州大学伯克利分校新的 QB3 研究所（定量生物医学研究所）内。该仪器将可供整个地区的研究人员使用。具体提案包括来自加州大学伯克利分校、斯坦福大学、加州大学旧金山分校、加州大学戴维斯分校、劳伦斯利弗莫尔国家实验室和基因泰克公司的研究人员的建议。使用仪器的时间将被分配到最大限度地应用到挑战当前核磁共振能力极限的问题。正在研究的系统将包括大型病毒和核糖体RNA、VS核酶、病毒蛋白-RNA相互作用、金属蛋白血红素加氧酶、TNF配体和受体相互作用、细菌转录激活剂、细胞内研究的蛋白质、细胞因子及其受体，以及参与DNA修复的蛋白质及其复合物。该设施的工作人员将提供对执行最先进的光谱学、脉冲序列库及其文档以及一般用户指南的支持。