Proposal for Central California 900 MHZ NMR Spectrometer

加州中部 900 MHZ 核磁共振波谱仪提案

• 批准号: 7254930
• 负责人: DAVID E WEMMER
• 金额: $ 24.77万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7254930
• 关键词: Area; Arts; Biomedical Research; California; Cells; Complex; DNA Repair; Documentation; Housing; Institutes; Libraries; Metalloproteins; Oxygenases; Physiologic pulse; Proteins; Pulse taking; Research Personnel; Ribosomal RNA; San Francisco; Spectrum Analysis; System; Time; Transcription Coactivator; Tumor Necrosis Factors; Universities; Viral; Viral Proteins; cytokine; instrument; member; receptor; varkud satellite ribozyme

DESCRIPTION (provided by applicant): A shared 900 MHz NMR facility will be established for the Central California area, to be housed in the new QB3 Institute (Institute for Quantitative Biomedical Research) at the University of California Berkeley. The instrument will be available to investigators throughout the region. Specific proposals are included from investigators at UC Berkeley, Stanford, UC San Francisco, UC Davis, Lawrence Livermore National Lab and Genentech. Time on the instrument will be allocated to maximize its application to problems which challenge the limits of current NMR capability. Systems under study will include large viral and ribosomal RNAs, VS ribozyme, viral protein-RNA interactions, metalloprotein heine oxygenases, TNF ligand and receptor interactions, bacterial transcriptional activators, proteins studied inside cells, cytokines and their receptors, and proteins involved in DNA repair and their complexes. Support for carrying out state of the art spectroscopy, libraries of pulse sequences and their documentation, and general user guides will be provided by staff members in the facility.

描述（由申请人提供）：将在加州中部地区建立一个共享的900 MHz NMR设施，该设施将设在加州伯克利大学的新QB 3研究所（定量生物医学研究所）。该仪器将提供给整个区域的调查人员。具体的建议包括来自加州大学伯克利分校，斯坦福大学，加州大学旧金山弗朗西斯科，加州大学戴维斯分校，劳伦斯利弗莫尔国家实验室和基因泰克的研究人员。仪器上的时间将被分配，以最大限度地将其应用于挑战当前核磁共振能力极限的问题。正在研究的系统将包括大型病毒和核糖体RNA、VS核酶、病毒蛋白-RNA相互作用、金属蛋白海涅加氧酶、TNF配体和受体相互作用、细菌转录激活因子、细胞内研究的蛋白质、细胞因子及其受体、参与DNA修复的蛋白质及其复合物。该设施的工作人员将为开展最先进的光谱学、脉冲序列库及其文档以及一般用户指南提供支持。

项目成果

A Benzyne Insertion Approach to Hetisine-Type Diterpenoid Alkaloids: Synthesis of Cossonidine (Davisine).

• DOI: 10.1021/jacs.8b05043
• 发表时间: 2018-07-05
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Kou KGM;Pflueger JJ;Kiho T;Morrill LC;Fisher EL;Clagg K;Lebold TP;Kisunzu JK;Sarpong R
• 通讯作者: Sarpong R

Evolution of a Synthetic Strategy for Complex Polypyrrole Alkaloids: Total Syntheses of Curvulamine and Curindolizine.

• DOI: 10.1021/jacs.0c13465
• 发表时间: 2021-02-24
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Xuan J;Haelsig KT;Sheremet M;Machicao PA;Maimone TJ
• 通讯作者: Maimone TJ

Total Synthesis of Altemicidin: A Surprise Ending for a Monoterpene Alkaloid.

• DOI: 10.1021/jacsau.3c00417
• 发表时间: 2023-10-23
• 期刊: JACS AU
• 影响因子: 8
• 作者: Harmange Magnani, Claire S;Hernandez-Melendez, Jose R;Tantillo, Dean J;Maimone, Thomas J
• 通讯作者: Maimone, Thomas J

Dearomative Synthetic Entry into the Altemicidin Alkaloids.

• DOI: 10.1021/jacs.1c04147
• 发表时间: 2021-06-02
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Harmange Magnani CS;Maimone TJ
• 通讯作者: Maimone TJ

Rapid Capture and Release of Nucleic Acids through a Reversible Photo-Cycloaddition Reaction in a Psoralen-Functionalized Hydrogel.

• DOI: 10.1002/anie.201711441
• 发表时间: 2018-02-23
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Zhang Y;Chan PPY;Herr AE
• 通讯作者: Herr AE