Competence to Consent in Schizophrenia Research

精神分裂症研究同意的能力

• 批准号: 6944226
• 负责人: Scott Y Kim
• 金额: $ 15.27万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6944226
• 关键词: antipsychotic agents; decision making; functional ability; human subject; informed consent; interview; longitudinal human study; patient oriented research; questionnaires; schizophrenia; suicide; videotape /videodisc

DESCRIPTION: A career development award is requested to allow the candidate to gain the skills required to become a leader in research ethics, with special expertise in determining competence for informed consent in individuals with decisional impairment. The focus will be on individuals with schizophrenia, because proposals to regulate research with persons with severe mental illness remain controversial. A key reason for this is the paucity of data directly answering the question: how should we translate dimensional, contextual data on decisional impairment into categorical judgments of competency status? To achieve his goal, the candidate will follow a career development plan that consists of: coursework and workshops to further develop his methodological skills, mentorship and consultation with recognized leaders in the field of competency research in both theoretical and empirical scholarly endeavors, and research studies on the competency determination process of individuals with schizophrenia being recruited into actual clinical trials. A model of competency determination process that includes three factors will be systematically examined: subject performance factors, contextual risk-benefit factors, and competency evaluator factors. The core research proposal is an ancillary study to the multi-site Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). It will examine the effect of subject performance factors on competency evaluators? judgments. The effect of degree and type of decisional impairment on competency judgments will be determined using receiver operating characteristics analysis, to determine thresholds for competence, and logistic regression, to characterize how the quality of impairment predicts competency status. In the later years of the Award period and beyond, the effect of the contextual risk-benefit factors and competency evaluator factors on final competency judgments will be examined using an innovative, internet-based format.

职位描述：要求获得职业发展奖，以使候选人能够

项目成果

Is psychiatric research stigmatized? An experimental survey of the public.

精神病学研究是否受到污名化？

• DOI: 10.1093/schbul/sbj003
• 发表时间: 2006
• 期刊: Schizophrenia bulletin.
• 作者: Muroff,JordanaR;Hoerauf,SarahL;Kim,ScottYH
• 通讯作者: Kim,ScottYH

Benefits and burdens of placebos in psychiatric research.

精神病学研究中安慰剂的益处和负担。

• DOI: 10.1007/s00213-003-1458-2
• 发表时间: 2003
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Kim,ScottYH

Burdens and benefits of placebos in antidepressant clinical trials: a decision and cost-effectiveness analysis.

抗抑郁药临床试验中安慰剂的负担和益处：决策和成本效益分析。

• DOI: 10.1176/appi.ajp.160.7.1272
• 发表时间: 2003
• 期刊: The American journal of psychiatry.
• 作者: Kim,ScottYH;Holloway,RobertG
• 通讯作者: Holloway,RobertG

Evidence-based ethics for neurology and psychiatry research.

神经病学和精神病学研究的循证伦理学。

• DOI: 10.1602/neurorx.1.3.372
• 发表时间: 2004
• 期刊: NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
• 作者: Kim,ScottYH

What do people at risk for Alzheimer disease think about surrogate consent for research?

• DOI: 10.1212/01.wnl.0000183144.61428.73
• 发表时间: 2005-11-08
• 期刊: NEUROLOGY
• 影响因子: 9.9
• 作者: Kim, SYH;Kim, HM;Tariot, PN
• 通讯作者: Tariot, PN