MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)

项目总结 该项目将建立和实施MACS/WIHS的布鲁克林临床研究站点(Bklyn CRS 联合队列研究(MACS/WIHS CCS)，并支持其推进临床、行为和 新诊断和慢性艾滋病毒感染及相关并存的流行病学。布克林区 CRS在社区的陪伴下，从25年的科学创新历史发展而来，并以此为基础 参与促进了布鲁克林妇女机构间艾滋病毒研究(WIHS)的严格执行。 Bklyn CRS将迅速发展出不同的男性和女性队列，反映出 艾滋病病毒在我们的地理区域。我们将包括对WIHS参与者的持续跟踪，他们贡献了丰富的 临床、生物、遗传、心理社会和行为数据的纵向历史来自中年和 更年轻的人，告知老年人口中艾滋病毒和老龄化的问题。Bklyn CRS调查人员将 制定和实施MACS/WIHS CCS统一科学议程的协议，为总体 行政基础设施的运作，并聘请一支强大的多学科研究团队 在解决创新科学方面。 我们的具体目标是：1)招募和保留500名艾滋病毒携带者和女性的预期队列 匹配的血清阴性对照并实施MACS/WIHS CCS研究方案；2)参与 多学科和经验丰富的科学家团队，开发和实施符合 配合和推进CCS统一科学议程；以及3)提供培训和职业发展 支持下一代艾滋病毒研究人员进步的机会。 Bklyn CRS在心血管疾病方面提供科学、管理和协作领导，并 相关的肺和睡眠结果；通过身体、功能和分子评估的衰老；心理 艾滋病毒自我管理和相关共病的社会环境方面；以及 神经认知和大脑老化。因此，Bklyn CRS将大大增强MACS/WIHS CCS，确保 研究问题的严谨性和相关性以及解决这些问题的方法。

PROJECT SUMMARY This project will establish and implement the Brooklyn Clinical Research Site (Bklyn CRS) of the MACS/WIHS Combined Cohort Study (MACS/WIHS CCS) and support its mission to advance the clinical, behavioral, and epidemiological science of newly diagnosed and chronic HIV infection and associated comorbidities. The Bklyn CRS evolves from and builds upon a 25-year history of scientific innovation accompanied by community engagement that facilitated rigorous implementation of the Brooklyn Women's Interagency HIV Study (WIHS). The Bklyn CRS will rapidly develop a diverse cohort of men and women reflecting the unique characteristics of HIV in our geographic area. We will include continued follow-up of WIHS participants, who contribute a rich longitudinal history of clinical, biologic, genetic, psychosocial and behavioral data derived from midlife and younger ages, informing questions of HIV and aging in an older population. The Bklyn CRS investigators will develop and implement protocols of the MACS/WIHS CCS Unified Science Agenda, contribute to the overall functioning of the administrative infrastructure, and engage a strong and multidisciplinary team of researchers in addressing innovative science. Our specific aims are to: 1) recruit and retain a prospective cohort of 500 men and women living with HIV and matched seronegative controls and implement MACS/WIHS CCS study protocols; 2) engage a multidisciplinary and experienced team of scientists to develop and implement innovative research that aligns with and advances the CCS Unified Science Agenda; and 3) provide training and career development opportunities to support advancement of the next generation of HIV researchers. The Bklyn CRS provides scientific, administrative and collaborative leadership in cardiovascular disease and associated lung and sleep outcomes; aging via physical, functional and molecular assessments; psychological and social environmental aspects of self-management of HIV and associated co-morbidities; and neurocognition and brain aging. As such, the Bklyn CRS will greatly enhance the MACS/WIHS CCS, ensuring the rigor and relevance of study questions and methods to address those questions.