MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)

项目摘要 本项目将建立和实施MACS/WIHS的布鲁克林临床研究中心（Bklyn CRS） 联合队列研究（MACS/WIHS CCS），并支持其使命，以促进临床，行为和 新诊断和慢性HIV感染及相关合并症的流行病学研究。布鲁克林酒店 CRS从25年的科学创新历史演变而来，并建立在社区的基础上， 参与促进严格执行布鲁克林妇女机构间艾滋病毒研究（WIHS）。 Bklyn CRS将迅速发展出一个多样化的男性和女性群体，反映出 艾滋病毒在我们的地理区域。我们将继续跟踪WIHS参与者，他们为我们提供了丰富的信息。 来自中年的临床、生物、遗传、心理社会和行为数据的纵向历史， 年轻人，告知艾滋病毒和老年人口老龄化的问题。Bklyn CRS调查人员将 制定和实施MACS/WIHS CCS统一科学议程的协议， 行政基础设施的运作，并聘请一个强大的和多学科的研究人员团队 in addressing处理innovative创新science科学. 我们的具体目标是：1）招募和保留500名艾滋病毒感染者， 匹配的血清阴性对照，并实施MACS/WIHS CCS研究方案; 2）聘请 多学科和经验丰富的科学家团队，以开发和实施创新研究， 与并推进CCS统一科学议程;和3）提供培训和职业发展 为下一代艾滋病毒研究人员的发展提供支持。 Bklyn CRS在心血管疾病方面提供科学，行政和协作领导， 相关的肺和睡眠结果;通过身体、功能和分子评估的衰老;心理 艾滋病毒自我管理和相关并发症的社会环境方面;以及 神经认知和大脑老化。因此，Bklyn CRS将大大增强MACS/WIHS CCS，确保 研究问题的严谨性和相关性以及解决这些问题的方法。

PROJECT SUMMARY This project will establish and implement the Brooklyn Clinical Research Site (Bklyn CRS) of the MACS/WIHS Combined Cohort Study (MACS/WIHS CCS) and support its mission to advance the clinical, behavioral, and epidemiological science of newly diagnosed and chronic HIV infection and associated comorbidities. The Bklyn CRS evolves from and builds upon a 25-year history of scientific innovation accompanied by community engagement that facilitated rigorous implementation of the Brooklyn Women's Interagency HIV Study (WIHS). The Bklyn CRS will rapidly develop a diverse cohort of men and women reflecting the unique characteristics of HIV in our geographic area. We will include continued follow-up of WIHS participants, who contribute a rich longitudinal history of clinical, biologic, genetic, psychosocial and behavioral data derived from midlife and younger ages, informing questions of HIV and aging in an older population. The Bklyn CRS investigators will develop and implement protocols of the MACS/WIHS CCS Unified Science Agenda, contribute to the overall functioning of the administrative infrastructure, and engage a strong and multidisciplinary team of researchers in addressing innovative science. Our specific aims are to: 1) recruit and retain a prospective cohort of 500 men and women living with HIV and matched seronegative controls and implement MACS/WIHS CCS study protocols; 2) engage a multidisciplinary and experienced team of scientists to develop and implement innovative research that aligns with and advances the CCS Unified Science Agenda; and 3) provide training and career development opportunities to support advancement of the next generation of HIV researchers. The Bklyn CRS provides scientific, administrative and collaborative leadership in cardiovascular disease and associated lung and sleep outcomes; aging via physical, functional and molecular assessments; psychological and social environmental aspects of self-management of HIV and associated co-morbidities; and neurocognition and brain aging. As such, the Bklyn CRS will greatly enhance the MACS/WIHS CCS, ensuring the rigor and relevance of study questions and methods to address those questions.