MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)

项目概要 该项目将建立并实施 MACS/WIHS 的布鲁克林临床研究中心 (Bklyn CRS) 联合队列研究 (MACS/WIHS CCS) 并支持其推进临床、行为和 新诊断和慢性艾滋病毒感染及相关合并症的流行病学。布莱克林 CRS 源于并建立在 25 年科学创新历史的基础上，并与社区相伴 的参与促进了布鲁克林妇女机构间艾滋病毒研究 (WIHS) 的严格实施。 Bklyn CRS 将迅速培养多元化的男性和女性群体，反映其独特的特征 我们地理区域的艾滋病毒。我们将持续跟踪 WIHS 参与者，他们贡献了丰富的成果 来自中年和中年的临床、生物学、遗传、心理社会和行为数据的纵向历史 更年轻的年龄，告知老年人口中的艾滋病毒和老龄化问题。 Bklyn CRS 调查人员将 制定和实施 MACS/WIHS CCS 统一科学议程的协议，为整体做出贡献 行政基础设施的运作，并聘请强大的多学科研究团队 解决创新科学问题。 我们的具体目标是：1) 招募并留住 500 名艾滋病毒感染者和女性患者的前瞻性队列 匹配血清阴性对照并实施 MACS/WIHS CCS 研究方案； 2）聘请 多学科且经验丰富的科学家团队开发和实施创新研究， 配合并推进 CCS 统一科学议程； 3）提供培训和职业发展 支持下一代艾滋病毒研究人员进步的机会。 Bklyn CRS 在心血管疾病和心血管疾病领域提供科学、行政和协作领导 相关的肺和睡眠结果；通过物理、功能和分子评估进行衰老；心理的 艾滋病毒自我管理和相关并发症的社会环境因素；和 神经认知和大脑衰老。因此，Bklyn CRS 将极大地增强 MACS/WIHS CCS，确保 研究问题以及解决这些问题的方法的严谨性和相关性。

PROJECT SUMMARY This project will establish and implement the Brooklyn Clinical Research Site (Bklyn CRS) of the MACS/WIHS Combined Cohort Study (MACS/WIHS CCS) and support its mission to advance the clinical, behavioral, and epidemiological science of newly diagnosed and chronic HIV infection and associated comorbidities. The Bklyn CRS evolves from and builds upon a 25-year history of scientific innovation accompanied by community engagement that facilitated rigorous implementation of the Brooklyn Women's Interagency HIV Study (WIHS). The Bklyn CRS will rapidly develop a diverse cohort of men and women reflecting the unique characteristics of HIV in our geographic area. We will include continued follow-up of WIHS participants, who contribute a rich longitudinal history of clinical, biologic, genetic, psychosocial and behavioral data derived from midlife and younger ages, informing questions of HIV and aging in an older population. The Bklyn CRS investigators will develop and implement protocols of the MACS/WIHS CCS Unified Science Agenda, contribute to the overall functioning of the administrative infrastructure, and engage a strong and multidisciplinary team of researchers in addressing innovative science. Our specific aims are to: 1) recruit and retain a prospective cohort of 500 men and women living with HIV and matched seronegative controls and implement MACS/WIHS CCS study protocols; 2) engage a multidisciplinary and experienced team of scientists to develop and implement innovative research that aligns with and advances the CCS Unified Science Agenda; and 3) provide training and career development opportunities to support advancement of the next generation of HIV researchers. The Bklyn CRS provides scientific, administrative and collaborative leadership in cardiovascular disease and associated lung and sleep outcomes; aging via physical, functional and molecular assessments; psychological and social environmental aspects of self-management of HIV and associated co-morbidities; and neurocognition and brain aging. As such, the Bklyn CRS will greatly enhance the MACS/WIHS CCS, ensuring the rigor and relevance of study questions and methods to address those questions.