Dietary Glycemic Load, Body Weight, and Blood Lipids

膳食血糖负荷、体重和血脂

• 批准号: 6875603
• 负责人: YUNSHENG MA
• 金额: $ 15.9万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875603
• 关键词: blood glucose; blood lipid; body physical activity; body weight; clinical research; dietary carbohydrates; glucose metabolism; human data; hyperlipidemia; longitudinal human study; nutrient requirement; nutritional epidemiology; seasons

DESCRIPTION (provided by applicant): The overall goal of this 2 year proposal is to examine the association of glycemic load (GL), derived from 24-hour dietary recalls, with body weight and blood lipids (including total cholesterol, LDL, HDL, and triglycerides), and to study seasonal and short-term variation of GL in a free-living healthy population. Results from short-term experimental studies and a limited number of observational studies suggest that GL, a measure of the quality and quantity of carbohydrate in foods, may be related to body weight and serum lipids, and GL potentially should be considered in dietary recommendations. However, neither the glycemic index (GI) nor GL is considered in the dietary guidelines of the American Heart Association, the U.S Department of Agriculture, or the American Diabetes Association. We will use dietary data collected from the Seasonal Variation in Blood Cholesterol Levels (SEASONS) (NHLBI: R01-HL52745) (1. Ockene - P.I.) study, in which 641 healthy adults in central Massachusetts were followed quarterly (baseline and four consecutive quarters: five sampling points in all) during this a one-year observational study. A total of fifteen 24-hour dietary and physical activity recalls were collected for each subject, with serum lipids and body weight measured five times. Serum lipids and body weight were measured once per quarter and three 24-hour recalls were administered (two weekdays and one weekend day) per quarter. If GL is found to be associated with body weight and blood lipids, a randomized clinical trial will be designed to evaluate the effects of a GL-based nutritional intervention program on hyperlipidemic patients. The methodology of this proposed study will involve several steps: 1) Data summarization of 9,067 24- hour diet recall records, 2) GL calculation and calculation of overall GI index, 3) Analysis of the relationship of GL to body weight and blood lipids, 4) Estimation of seasonal and short-term variations in GL, 5) Analysis of GL by meal type and identification of the top ten food contributors, 6) Analysis of the association of overall GI with body weight and blood lipids, and 7) Final report and manuscript preparation.

描述(由申请人提供)：这项为期两年的提案的总体目标是研究血糖负荷(GL)与体重和血脂(包括总胆固醇、低密度脂蛋白、高密度脂蛋白和甘油三酯)之间的关系，并研究自由生活的健康人群中血糖负荷的季节性和短期变化。 短期实验研究和有限数量的观察性研究的结果表明，GL--一种衡量食物中碳水化合物质量和数量的指标--可能与体重和血脂有关，因此GL可能应被考虑在饮食建议中。然而，美国心脏协会、美国农业部或美国糖尿病协会的饮食指南中都没有考虑血糖指数(GI)或GL。 我们将使用从血液胆固醇水平的季节变化(NHLBI：R01-HL52745)(1.Ockene-P.I.)收集的饮食数据。在这项为期一年的观察性研究中，对马萨诸塞州中部的641名健康成年人进行了季度跟踪(基线和连续四个季度：总共五个采样点)。每个受试者总共收集了15次24小时饮食和体力活动回忆，并测量了5次血脂和体重。每季度测量一次血脂和体重，每季度进行三次24小时召回(两个工作日和一个周末)。如果GL被发现与体重和血脂有关，将设计一项随机临床试验，以评估基于GL的营养干预计划对高脂血症患者的效果。这项研究的方法包括几个步骤：1)9,067个24小时饮食召回记录的数据汇总；2)GL计算和计算总体GI指数；3)分析GL与体重和血脂的关系；4)估计GL的季节性和短期变化；5)按膳食类型分析GL并确定前十大食物贡献者；6)分析总体GI与体重和血脂的关系；以及7)最终报告和稿件的准备。