VASCULAR RESEARCH TRAINING

(摘自申请者的摘要)本培训计划的目标是 为医生(医学博士和医学博士/博士)提供实验室研究培训。和 血管生物学博士后科学家，为职业生涯做准备 作为血管生物学相关学科的独立调查人员。 受训人员的选择将基于对血管的承诺 生物学及以前较强的研究经验或潜质。未来 医生-科学家是这一培训计划的主要目标。三年 每名实习生需要为三名博士后研究员提供支持 该项目的第一年。耶鲁大学分子心脏生物学研究所 医学的博耶分子医学中心和心血管 内科医学部，将是 该计划。然而，由于血管生物学遍及广泛的 临床医学和基础生物学研究，该计划将与 多个临床和基础科学科室。对此的证词是 主要参与教职员的院系关系，包括 内科(心肺内科)、病理学、 遗传学、免疫生物学、生理学和生物学。跨部门 耶鲁大学的血管研究社区将通过这次培训团结起来 计划和提供以下领域的研究机会：1)分子 白细胞-内皮细胞相互作用的决定因素和后果：2) 调节血管细胞凋亡和抗凋亡信号；3)作用 凝血蛋白对血管细胞的激活和损伤；4)凝血蛋白的作用 抗内皮细胞同种异体反应中的细胞因子和膜受体；5)体内 同种和异种移植模型中血管基因的传递；6)调节 血管细胞对缺氧的反应中的细胞保护基因；7)使用 评价G蛋白介导的信号转导的遗传学方法 真核生物；8)血管细胞整合素生物学，包括控制黏附和 参与的分子后果；9)使用化学遗传方法 研究抗血管生成化合物；10)鉴定和定位 有助于人类血管疾病的发展，通过分子 基因技术；11)神经体液和细胞的微循环分析 控制血管运动的耦合机制；以及12)调节 内皮细胞一氧化氮在正常生理和疾病中的释放。这位大姐 血管研究基础强调血管的强度和广度 耶鲁大学医学院的生物学，并突出了众多研究 为博士后实习生提供机会。一个强大的教育课程将 提供，包括专门为博士后研究员开设的授课课程， 研究生院内的课程，以及基于计划的课程和 多部门研究研讨会和期刊俱乐部。进展将是 通过几个机制进行监测，包括个别受训人员的进展情况 委员会。

(Adapted from applicant's abstract) The goal of this training program is to provide laboratory research training for physician (M.D. and M.D./Ph.D.) and Ph.D. postdoctoral scientists in vascular biology, in preparation for careers as independent investigators in blood vessel biology-related disciplines. Selection of trainees will be based on a demonstrated commitment to vascular biology and strong prior research experience or potential of same. Future physician-scientists are major targets for this training program. Three years of support, per trainee, are requested, for three postdoctoral fellows in the first year of the program. The Molecular Cardiobiology Unit at Yale School of Medicine's Boyer Center for Molecular Medicine, and the Cardiovascular Medicine Division of Internal Medicine, will be the central foundations for the Program. However, because vascular biology pervades wide areas of clinical medicine and basic biologic research, the program will interact with multiple clinical and basic science departments. Testimonies to that are the departmental affiliations of the primary participating faculty, which include Internal Medicine (Pulmonary and Cardiovascular Medicine), Pathology, Genetics, Immunobiology, Physiology and Biology. The interdepartmental vascular research community at Yale will coalesce through this training program and provide research opportunities in the following area: 1) molecular determinants and consequences of leukocyte-endothelial cell interactions: 2) regulation of vascular apoptotic and anti-apoptotic signals; 3) effects of coagulation proteins on vascular cell activation and injury; 4) the role of cytokines and membrane receptors in anti-endothelial alloresponses; 5) in vivo vascular gene delivery in allo- and xenograft models; 6) regulation of cytoprotective genes in vascular cells in response to hypoxia; 7) use of genetic methods to evaluate G protein-mediated signal transduction in eukaryotes; 8) vascular cell integrin biology, both control of adhesion and molecular consequences of engagement; 9) use of chemical genetic approaches to study anti-angiogenic compounds; 10) identification and mapping of genes that contribute to the development of vascular disease in humans, through molecular genetic techniques; 11) microcirculatory analysis of neurohumoral and cell coupling mechanisms which control vasomotion; and 12) regulation of endothelial nitric oxide release in normal physiology and disease. This broad base of vascular research underscores the strength and breadth of vascular biology at the Yale School of Medicine, and highlights the numerous research opportunities for postdoctoral trainees. A strong educational curriculum will be provided, including didactic courses specifically for postdoctoral fellows, courses within the graduate school, as well as both program-based and multi departmental research seminars and journal clubs. Progress will be monitored through several mechanisms, including individual trainee progress committees.