VASCULAR RESEARCH TRAINING

血管研究培训

• 批准号: 6901872
• 负责人: JEFFREY R. BENDER
• 金额: $ 37.24万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6901872
• 关键词: VASCULAR; RESEARCH; TRAINING

(Adapted from applicant's abstract) The goal of this training program is to provide laboratory research training for physician (M.D. and M.D./Ph.D.) and Ph.D. postdoctoral scientists in vascular biology, in preparation for careers as independent investigators in blood vessel biology-related disciplines. Selection of trainees will be based on a demonstrated commitment to vascular biology and strong prior research experience or potential of same. Future physician-scientists are major targets for this training program. Three years of support, per trainee, are requested, for three postdoctoral fellows in the first year of the program. The Molecular Cardiobiology Unit at Yale School of Medicine's Boyer Center for Molecular Medicine, and the Cardiovascular Medicine Division of Internal Medicine, will be the central foundations for the Program. However, because vascular biology pervades wide areas of clinical medicine and basic biologic research, the program will interact with multiple clinical and basic science departments. Testimonies to that are the departmental affiliations of the primary participating faculty, which include Internal Medicine (Pulmonary and Cardiovascular Medicine), Pathology, Genetics, Immunobiology, Physiology and Biology. The interdepartmental vascular research community at Yale will coalesce through this training program and provide research opportunities in the following area: 1) molecular determinants and consequences of leukocyte-endothelial cell interactions: 2) regulation of vascular apoptotic and anti-apoptotic signals; 3) effects of coagulation proteins on vascular cell activation and injury; 4) the role of cytokines and membrane receptors in anti-endothelial alloresponses; 5) in vivo vascular gene delivery in allo- and xenograft models; 6) regulation of cytoprotective genes in vascular cells in response to hypoxia; 7) use of genetic methods to evaluate G protein-mediated signal transduction in eukaryotes; 8) vascular cell integrin biology, both control of adhesion and molecular consequences of engagement; 9) use of chemical genetic approaches to study anti-angiogenic compounds; 10) identification and mapping of genes that contribute to the development of vascular disease in humans, through molecular genetic techniques; 11) microcirculatory analysis of neurohumoral and cell coupling mechanisms which control vasomotion; and 12) regulation of endothelial nitric oxide release in normal physiology and disease. This broad base of vascular research underscores the strength and breadth of vascular biology at the Yale School of Medicine, and highlights the numerous research opportunities for postdoctoral trainees. A strong educational curriculum will be provided, including didactic courses specifically for postdoctoral fellows, courses within the graduate school, as well as both program-based and multi departmental research seminars and journal clubs. Progress will be monitored through several mechanisms, including individual trainee progress committees.

（根据申请人的摘要改编）该培训计划的目标是 为医师提供实验室研究培训（M.D。和M.D./ph.d。）和 博士血管生物学的博士后科学家为职业做准备 作为血管生物学相关学科的独立研究者。 选择学员将基于对血管的表现承诺 生物学和强大的先前研究经验或潜力。 未来 医师科学家是该培训计划的主要目标。 三年 要求每个受训者的支持，用于三个博士后研究员 计划的第一年。 耶鲁学校的分子心生物学单元 医学的Boyer分子医学中心和心血管 内科医学司将是 该程序。 但是，由于血管生物学遍布 临床医学和基本生物学研究，该计划将与 多个临床和基础科学部门。 证词是 主要参与教师的部门隶属关系，其中包括 内科（肺和心血管医学），病理学， 遗传学，免疫生物学，生理学和生物学。 部门间 耶鲁大学的血管研究社区将通过这项培训结合 计划并在以下领域提供研究机会：1）分子 白细胞 - 内皮细胞相互作用的决定因素和后果：2） 调节血管凋亡和抗凋亡信号； 3）效果 血管细胞激活和损伤的凝结蛋白； 4）角色 抗内皮同种酶中的细胞因子和膜受体； 5）体内 同种和异种移植模型中的血管基因递送； 6）调节 血管细胞中的细胞保护基因响应缺氧； 7）使用 评估G蛋白介导的信号转导的遗传方法 真核生物； 8）血管细胞整联蛋白生物学，粘附的控制和 参与的分子后果； 9）使用化学遗传方法 研究抗血管生成化合物； 10）识别和映射基因 通过分子有助于人类血管疾病的发展 遗传技术； 11）神经浮游物和细胞的微循环分析 控制血管症的耦合机制； 12）调节 正常生理和疾病中的内皮一氧化氮释放。 这个广泛 血管研究的基础强调了血管的强度和广度 耶鲁大学医学院的生物学，并强调了众多研究 博士后学员的机会。 强大的教育课程将 提供，包括专门针对博士后研究员的教学课程， 研究生院内的课程以及基于计划的课程和 多部门研究研讨会和期刊俱乐部。 进度将是 通过几种机制进行监控，包括个人学员进步 委员会。