Multidisciplinary Research Training in Pediatric Pulmonary Vascular Disease

小儿肺血管疾病多学科研究培训

• 批准号: 10673931
• 负责人: Steven Herbert Abman
• 金额: $ 37.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673931
• 关键词: Childhood; Interdisciplinary Study; Research Training; pulmonary vascular disorder

PROJECT SUMMARY/ABSTRACT Pulmonary vascular disease (PVD) is a significant source of morbidity and mortality in neonates, infants and children with diverse heart, lung and systemic diseases. A major barrier to improving outcomes of children with PVD is the fundamental lack of understanding the differing pathobiologies among the spectrum of these disorders, which intersect between multiple clinical disciplines. This is compounded by the scarcity of training opportunities to develop and retain physician-scientists and scientists with expertise in PVD that allows for the successful translation of laboratory and clinical science across multiple disciplines. Thus, there is a need for well-trained scientists in Pediatric PVD who can perform collaborative and rigorous inter-disciplinary investigation to enhance the development of new treatment modalities. This novel application requests the resources to establish a unique two-year post-doctoral collaborative research training program in Pediatric PVD within the Departments of Pediatrics at the University of California, San Francisco, the University of Colorado, and Vanderbilt University. The goal of the program is to increase the number of highly trained, successfully funded and sustainable pediatric pulmonary vascular scientists, who will perform high level laboratory, clinical- translational, and/or health services research that will ultimately improve our understanding of the pathobiology of diverse pediatric PVD, design therapeutic plans that specifically target an individual’s underlying pathobiology, and thereby improve both short and long-term outcomes. To this end, this program aims to provide comprehensive scientific training through novel mentoring and collaborative approaches to enhance career development for physicians or post-doctorate scientists with an M.D., M.D./Ph.D. or Ph.D., who commit themselves to an academic career in pediatric PVD. The key and unique elements of this training program are: (1) a rich, diverse, mentored research experience; (2) interdisciplinary and inter-institutional experiences, including joint didactic learning opportunities, with direct integration into the North American Pediatric Pulmonary Hypertension Network and the associated Annual International Conference; and (3) continuous review and evaluation from academic leaders in the field. The centerpiece of the program for pediatric-scientists is the continuation of a 4-year fellowship training program (including but not limited to Pediatric Cardiology, Critical Care, Emergency Medicine, Neonatology, or Pulmonology), with 2 years devoted to intense research training in basic laboratory science, clinical-translational science, health services or epidemiology related to pediatric PVD. Exceptional faculty have committed their support as mentors, who lead and are affiliated with several of their universities’ research units and clinical programs, a represent a “critical mass” that few single centers can provide. Thus, the rationale for this novel proposal is based on the need for well-designed training programs in Pediatric PVD research, including the need to foster multi-disciplinary and multi-interdisciplinary collaborative approaches, and that these three institutions have the vision, experience, and collaborative infrastructure to train the next generation of leaders.

项目总结/摘要 肺血管疾病（PVD）是新生儿、婴儿和新生儿中发病率和死亡率的重要来源。 患有各种心脏、肺部和全身性疾病的儿童。改善儿童预后的一个主要障碍是， PVD是对这些疾病谱中不同病理生物学的根本缺乏了解。 这些疾病在多个临床学科之间交叉。培训的缺乏使这一问题更加复杂 培养和留住具有PVD专业知识的医生科学家和科学家的机会， 跨多个学科成功翻译实验室和临床科学。因此，需要 训练有素的儿科PVD科学家，他们可以进行协作和严格的跨学科研究 加强新的治疗方式的发展。这个新的应用程序请求资源， 在儿科PVD领域建立一个独特的为期两年的博士后合作研究培训计划， 加州大学、旧金山弗朗西斯科大学、科罗拉多大学和 范德比尔特大学。该计划的目标是增加训练有素、成功资助的 和可持续的儿科肺血管科学家，他们将进行高水平的实验室，临床- 翻译和/或卫生服务研究，最终将提高我们对疾病病理学的理解。 多样化的儿科PVD，设计专门针对个体潜在病理学的治疗计划， 从而改善短期和长期的结果。为此，该计划旨在提供全面的 通过新颖的指导和协作方法进行科学培训， 拥有医学博士学位的医生或博士后科学家，医学博士/博士或博士学位，他们致力于 儿科PVD的学术生涯。这个培训计划的关键和独特的元素是：（1）丰富，多样， 指导研究经验;（2）跨学科和机构间经验，包括联合教学 学习机会，直接融入北美儿科肺动脉高压网络 以及相关的年度国际会议;（3）学术界的持续审查和评估 领导者在外地。儿科科学家计划的核心是延续4年的奖学金 培训计划（包括但不限于儿科心脏病学，重症监护，急诊医学， 新生儿学或肺病学），2年致力于基础实验室科学的密集研究培训， 与儿科PVD相关的临床转化科学、卫生服务或流行病学。优秀的教师有 他们承诺作为导师提供支持，导师领导并隶属于他们大学的几个研究单位 和临床项目，代表了一个“临界质量”，很少有单一的中心可以提供。因此， 一个新的建议是基于对儿科PVD研究中精心设计的培训计划的需求，包括 需要促进多学科和多学科间的合作方法，这三个 各院校拥有培养下一代领导人的远见、经验和协作基础设施。

项目成果

Sex differences in endothelial cell function: an evolving explanation of sex differences in preterm infant pulmonary outcomes.

内皮细胞功能的性别差异：早产儿肺部结局性别差异的不断发展的解释。

• DOI: 10.1152/ajpheart.00718.2022
• 发表时间: 2023
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Cookson,MichaelW;Sherlock,LauraG
• 通讯作者: Sherlock,LauraG

Persistence of persistent pulmonary hypertension of the newborn: A case of de novo TBX4 variant.

• DOI: 10.1002/pul2.12108
• 发表时间: 2022-07
• 期刊: PULMONARY CIRCULATION
• 影响因子: 2.6
• 作者: Tsoi, Stephanie M.;Jones, Kirk;Colglazier, Elizabeth;Parker, Claire;Nawaytou, Hythem;Teitel, David;Fineman, Jeffrey R.;Keller, Roberta L.
• 通讯作者: Keller, Roberta L.