NERVOUS SYSTEM DEVELOPMENT AND INJURY

描述（由申请人提供） 本申请寻求继续资助两个培训项目， 华盛顿大学是一所由美国政府和美国政府共同管理的大学。 神经内科和神经外科在过去的19年里， 另一种是由儿科神经科管理的， 在过去的八年里后者是神经科学学术 发展奖，不能续聘。我们寻求提供一个扩展的计划， 为选定的神经病学，神经外科或 小儿神经病学，为学术生涯做准备。以利用 在过去几年中，我们在转化神经科学研究方面取得了进展， 我们的培训计划更加强调以病人为导向， research.因此，我们打算增加我们对板凳研究的历史重点 通过为我们的学员提供获得严格教育的机会， 临床研究方法学 我们相信，未来的临床进展 神经病学和神经外科学将由研究人员进行实践， 联合收割机结合临床专业知识与正规教育在这方面的方法。学员 参加我们的培训计划，预计将投入至少两个 多年来，除了住院医师培训之外，几乎全职工作。这是 可能是培养受过科学训练的人所需的最低期限。 神经或神经外科临床医生，他们将是阐明 神经系统疾病的发病机制，并带来新的治疗方法， 患者尽管神经科学研究的进展在加速， 目前，严重缺乏神经或神经外科 医生科学家或临床研究人员能够执行这些 重要的翻译功能。事实上，美国神经病学 协会目前列出了150多个学术神经病学的空缺职位 一个人 利用现有的优势，无论是在培训单位本身 （神经病学，神经外科学和儿科神经病学），并在较大的 华盛顿大学神经科学社区，拟议的计划将 继续关注两大主题：神经系统损伤和神经系统损伤。 系统开发。这两个主题是与疾病有关的 神经科学的今天，相关的了解发病机制，许多 不同的神经系统疾病这些主题相辅相成， 部分重叠。深入了解发展中国家的性质 神经系统很可能与理解神经系统有关 对伤害的反应。

DESCRIPTION (provided by applicant) The present application seeks continued funding for two training programs at Washington University, one that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 19 years, and another that has been administered by the Division of Pediatric Neurology for the past eight years. The latter, the Neurological Sciences Academic Development Award, cannot be renewed. We seek to provide a program of extended research training for selected trainees in Neurology, Neurosurgery, or Pediatric Neurology, preparing for academic careers. To take advantage of progress in translational neuroscience research over the last few years, we have increased the emphasis of our training program on patient-oriented research. We thus intend to augment our historical emphasis on bench research by offering our trainees the opportunity to gain a rigorous education in clinical research methodology. We believe that the next advances in clinical neurology and neurosurgery will be brought into practice by investigators who combine clinical expertise with formal education in this methodology. Trainees participating in our training program will be expected to devote at least two years of near full-time effort beyond residency training to the task. This is likely the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinicians who will be essential for elucidating the pathogenesis of nervous system diseases, and bringing new therapies to patients. Despite accelerating neuroscience research advances, there is presently a serious shortage of neurological or neurosurgical physician-scientists or clinical researchers capable of performing these essential translational functions. Indeed, the American Neurological Association currently lists over 150 open positions in academic neurology alone. Exploiting current strengths, both within the training units themselves (Neurology, Neurosurgery, and Pediatric Neurology), and within the larger neuroscience community at Washington University, the proposed program will continue to focus on two major themes: Nervous System Injury, and Nervous System Development. These twin themes are active fronts in disease-related neuroscience today, relevant to understanding the pathogenesis of many different neurological diseases. These themes are complementary, as well as partially overlapping. Insights gained into the nature of the developing nervous system are highly likely to be relevant to understanding nervous system responses to injury.