ROLE OF THE GUT IN POST INJURY MULTIPLE ORGAN FAILURE

肠道在损伤后多器官衰竭中的作用

• 批准号: 6910681
• 负责人: FREDERICK A MOORE
• 金额: $ 13.45万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-02 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6910681
• 关键词: ROLE; GUT; POST; INJURY; MULTIPLE

EXCEED THE SPACE PROVIDED. PROJECT SUMMARY: The longterm objective of this training program is to produce academically competitive traumatologists who can design and execute laboratory models to test clinically relevant lypotheses, collaborate with other types of scientists to enhance the basic understanding of the problem they are studying and translate this information back to the clinical arena. The program is primarily derived from the faculty and research laboratories that participate in the NIGMS sponsored Trauma Research Center (TRC) at The University of Texas - Houston Medical School. The program recruits primarily MDs(principally surgeons) who are interested in pursuing trauma related research as a career goal. The trainees will be immersed into an integrated research effort that continuesto evolve as the TRC pursues its research theme of elucidating the role of the gastrointestinal tract in the pathogenesis of multiple organ failure. The administrative structure of the program is coordinated by the Program Director (Frederick A, Moore, MD), Associate Program Director (David W. Mercer, MD), and the Executive Committee. Each trainee has a primary mentor. The mentor is responsible for helping the trainee 1) formulate a focused research proposal, 2) access laboratory supplies, equipment and technical instruction necessary to perform the required experiments, 3) analyze the results, develop conclusions, and revise experimental strategies, and 4) organize both oral and written presentations. The cornerstone of the training program is TRC's weekly Friday meetings where the trainees present their evolving research and learn by example how to critique and modify research proposals. Additionally,the trainees participate in formal course work including 1) Fundamentals of Surgical Research Workshop, 2) Clinical Research Curriculum,3) The Ethical Dimensions of the Biomedical Sciences, and 4) Center for Laboratory Animal Medicine and Care Research Training courses. The trainees will submit abstracts and present their data at national meetings, prepare manuscripts for peer review publication, and present a Surgical Grand Rounds lecture related to their research. At the end of the two year training program, the trainee will be capable of writing a competitive research proposal. RELEVANCE: Trauma is a serious healthcare problem. It is the third leading cause of death (behind heart disease and cancer) and is the leading cause of long-term disability. This program will train the future clinical scientists who will work with other types of scientists to increase basic understanding of trauma related illness and take this information back to the bedside to improve the care of severely injured patients. PERFORMANCE SITE ========================================Section End===========================================

超出所提供的空间。项目摘要：该培训计划的长期目标是培养具有学术竞争力的创伤学家，他们可以设计和执行实验室模型来测试临床相关的溶血术，与其他类型的科学家合作，以增强对他们正在研究的问题的基本理解，并将这些信息转化回临床领域。该计划主要源自参加 NIGMS 赞助的德克萨斯大学休斯顿医学院创伤研究中心 (TRC) 的教员和研究实验室。该项目主要招募有兴趣将创伤相关研究作为职业目标的医学博士（主要是外科医生）。学员将沉浸在一项综合研究工作中，该研究工作随着 TRC 追求其研究主题而不断发展，即阐明胃肠道在多器官衰竭发病机制中的作用。该计划的行政结构由计划主任（医学博士 Frederick A Moore）、项目副主任（医学博士 David W. Mercer）和执行委员会负责协调。每个学员都有一位主要导师。导师负责帮助学员 1) 制定重点研究计划，2) 获取进行所需实验所需的实验室用品、设备和技术指导，3) 分析结果、得出结论并修改实验策略，4) 组织口头和书面演示。培训计划的基石是 TRC 每周周五举行的会议，学员在会上展示他们不断发展的研究，并通过实例学习如何批评和修改研究提案。此外，学员还参加正式课程，包括 1) 外科研究基础研讨会、2) 临床研究课程、3) 生物医学科学的伦理维度，以及 4) 实验动物医学和护理研究中心培训课程。学员将在全国会议上提交摘要并展示他们的数据，准备同行评审出版的手稿，并进行与他们的研究相关的外科大查房讲座。在两年的培训计划结束时，受训者将能够撰写有竞争力的研究计划。相关性：创伤是一个严重的医疗保健问题。它是第三大死亡原因（仅次于心脏病和癌症），也是导致长期残疾的主要原因。该计划将培训未来的临床科学家，他们将与其他类型的科学家合作，增加对创伤相关疾病的基本了解，并将这些信息带回到床边，以改善对严重受伤患者的护理。表演网站==========================================章节结束===============================================