Role of the Gut in Post-Injury Multiple Organ Failure

描述(由申请人提供) 项目摘要：该培训计划的长期目标是培养具有学术竞争力的创伤专家，他们能够设计和执行实验室模型来测试临床相关的假设，与其他类型的科学家合作，以增强对他们正在研究的问题的基本理解，并将这些信息转化回临床领域。该计划主要来源于参与NIGMS赞助的德克萨斯大学休斯顿医学院创伤研究中心(TRC)的教职员工和研究实验室。该计划主要招募医学博士(主要是外科医生)，他们对从事创伤相关研究感兴趣，并将其作为职业目标。受训者将沉浸在一项综合研究工作中，随着TRC继续其研究主题，阐明胃肠道在多器官衰竭发病机制中的作用，这项工作将继续发展。该计划的管理结构由计划主任(马里兰州弗雷德里克·A·摩尔)、副计划主任(大卫·W·默瑟，马里兰州)和执行委员会协调。每个学员都有一名主要导师。导师负责帮助学员1)制定有重点的研究方案，2)获得执行所需实验所需的实验室用品、设备和技术指导，3)分析结果，得出结论，修改实验策略，4)组织口头和书面陈述。培训计划的基石是TRC每周一次的周五会议，受训人员在会上介绍他们不断发展的研究，并通过实例学习如何批评和修改研究建议。此外，受训人员还参加正式的课程工作，包括1)外科研究基础工作坊，2)临床研究课程，3)生物医学科学的伦理层面，以及4)实验动物医学和护理研究中心的培训课程。受训者将提交摘要并在全国会议上展示他们的数据，准备手稿以供同行审阅出版，并发表与他们的研究相关的外科大讲座。在为期两年的培训计划结束后，学员将能够撰写一份竞争性的研究提案。 相关性：创伤是一个严重的医疗保健问题。它是第三大致死原因(仅次于心脏病和癌症)，也是导致长期残疾的首要原因。该计划将培训未来的临床科学家，他们将与其他类型的科学家合作，增加对创伤相关疾病的基本了解，并将这些信息带回床边，以改善对严重受伤患者的护理。

DESCRIPTION (provided by applicant) Project Summary: The long-term objective of this training program is to produce academically competitive traumatologists who can design and execute laboratory models to test clinically relevant hypotheses, collaborate with other types of scientists to enhance the basic understanding of the problem they are studying and translate this information back to the clinical arena. The program is primarily derived from the faculty and research laboratories that participate in the NIGMS-sponsored Trauma Research Center (TRC) at the University of Texas-Houston Medical School. The program recruits primarily MDs (principally surgeons) who are interested in pursuing trauma related research as a career goal. The trainees will be immersed into an integrated research effort that continues to evolve as the TRC pursues its research theme of elucidating the role of the gastrointestinal tract in the pathogenesis of multiple organ failure. The administrative structure of the program is coordinated by the Program Director (Frederick A. Moore, MD), Associate Program Director (David W. Mercer, MD), and the Executive Committee. Each trainee has a primary mentor. The mentor is responsible for helping the trainee 1) formulate a focused research proposal, 2) access laboratory supplies, equipment and technical instruction necessary to perform the required experiments, 3) analyze the results, develop conclusions, and revise experimental strategies, and 4) organize both oral and written presentations. The cornerstone of the training program is TRC's weekly Friday meetings where the trainees present their evolving research and learn by example how to critique and modify research proposals. Additionally, the trainees participate in formal course work including 1) Fundamentals of Surgical Research Workshop, 2) Clinical Research Curriculum, 3) The Ethical Dimensions of the Biomedical Sciences, and 4) Center for Laboratory Animal Medicine and Care Research Training courses. The trainees will submit abstracts and present their data at national meetings, prepare manuscripts for peer-reviewed publication, and present a Surgical Grand Rounds lecture related to their research. At the end of the two-year training program, the trainee will be capable of writing a competitive research proposal. Relevance: Trauma is a serious health care problem. It is the third leading cause of death (behind heart disease and cancer) and is the leading cause of long-term disability. This program will train the future clinical scientists who will work with other types of scientists to increase basic understanding of trauma related illness and take this information back to the bedside to improve the care of severely injured patients.