PROGRAM IN MOLECULAR AND COMPUTATIONAL BIOPHYSICS

分子和计算生物物理学项目

• 批准号: 6845041
• 负责人: DAVID E. DRAPER
• 金额: $ 69.49万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6845041
• 关键词: PROGRAM; MOLECULAR; COMPUTATIONAL; BIOPHYSICS

DESCRIPTION (provided by applicant): The Program in Molecular and Computational Biophysics is seeking to renew its training grant. The Jenkins Department of Biophysics (Arts & Sciences, Homewood campus) and the Department of Biophysics and Biophysical Chemistry (School of Medicine, East Baltimore campus) form the core of the program with respect to administration and curriculum; 44 faculty, drawn from 15 departments and about evenly divided between the two campuses, participate in training activities. Students freely move between campuses and laboratories for course work, rotations, and thesis research. The training faculty roster has grown to include more faculty working in areas of NMR, X-ray crystallography, membrane proteins, computational biophysics, and biochemical transformations. The 44 participating laboratories have a strong sense of community engendered by activities such as an annual retreat, a monthly evening Biophysical Discussion, and the biennial Johns Hopkins Folding Meeting. Faculty also have access to shared instrumentation facilities for X-ray crystallography, ultracentrifugation, and high field NMR. In the first year, students take four core courses specifically designed for the program: Physical Chemistry of Biological Macromolecules; Proteins and Nucleic Acids; Methods in Molecular Biophysics; and Computer Modeling of Biological Macromolecules; the courses have recently been revamped to increase literature readings, classroom time devoted to discussion, and computer programming exercises in the curriculum. The course work has a heavier emphasis on quantitative analysis and fundamental physical principles than most biologically-oriented training programs. First year students also complete three 10 week lab rotations and attend a lecture series on Responsible Conduct of Research; a lab safety presentation is compulsory. At the end of the year, they must demonstrate proficiency in biochemistry and molecular and cellular biology in an oral exam. Second year students take Organic Mechanisms in Biology and three electives; students in a computational track substitute Statistical Mechanics for an elective. Second year students also present a formal seminar on a current topic in biophysics and take an oral qualifying exam. Currently 16 first and second year students are supported by the program, out of a total of 43 program students. Four program students are supported by a one-time grant from the Burroughs Wellcome Foundation designed to encourage students with math- and computer-intensive backgrounds to move into biological research; this program has in essence been continued with a supplement awarded in 2003 for recruitment of students into a computational track.

描述（由申请人提供）：分子和计算生物物理学项目正在寻求更新其培训补助金。詹金斯生物物理学系（艺术与科学，霍姆伍德校区）和生物物理学和生物物理化学系（医学院，东巴尔的摩校区）构成了该项目在管理和课程方面的核心；来自 15 个系、大约分布在两个校区的 44 名教职人员参加了培训活动。学生可以在校园和实验室之间自由流动，进行课程作业、轮换和论文研究。培训教师名单不断扩大，包括更多从事核磁共振、X 射线晶体学、膜蛋白、计算生物物理学和生化转化领域工作的教师。 44 个参与实验室通过年度静修会、每月晚间生物物理讨论和两年一次的约翰·霍普金斯折叠会议等活动产生了强烈的社区意识。教师还可以使用 X 射线晶体学、超速离心和高场核磁共振的共享仪器设施。 第一年，学生学习专为该项目设计的四门核心课程：生物大分子物理化学；蛋白质和核酸；分子生物物理学方法；和生物大分子的计算机建模；这些课程最近进行了修改，以增加课程中的文学阅读、用于讨论的课堂时间以及计算机编程练习。与大多数生物导向的培训项目相比，该课程更注重定量分析和基本物理原理。一年级学生还完成了三次为期 10 周的实验室轮换，并参加了关于负责任的研究行为的系列讲座；实验室安全演示是强制性的。年底，他们必须在口试中证明自己对生物化学以及分子和细胞生物学的熟练程度。二年级学生选修生物学有机机制和三门选修课；计算方向的学生用统计力学代替选修课。二年级学生还就当前生物物理学主题举办正式研讨会，并参加口语资格考试。目前，共有 43 名项目学生，其中 16 名一年级和二年级学生受到该项目的支持。四名项目学生得到了 Burroughs Wellcome 基金会的一次性资助，该资助旨在鼓励具有数学和计算机背景的学生进入生物研究领域；该计划本质上是继续进行的，并于2003年为招收学生进入计算领域提供了补充。