The biophysics of phase separation in motor neurone disease.

运动神经元疾病相分离的生物物理学。

• 批准号: 2493915
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2493915
• 关键词: biophysics; phase; separation; motor; neurone

Aggregation of amyloidogenic proteins hasbeen associated with a wide variety of pathologies within the human body, including some neurodegenerative disorders. However,the mechanism of pathogenesisfor these diseases, and the role of amyloid proteins in them, is often poorly understood. One such example is the aggregation of TDP43, which is linked to the development of motor neurone disease (MND).While TDP43 has been widely studied thus far, a second type of intraneuronalinclusion body, called the Bunina body, has also been associated with MND, but has yet to be properly characterise

淀粉样蛋白的聚集与人体内多种病理学有关，包括一些神经退行性疾病。然而，这些疾病的发病机制，以及淀粉样蛋白在其中的作用，往往知之甚少。一个这样的例子是TDP43的聚集，它与运动神经元疾病（MND）的发展有关。虽然TDP43迄今已被广泛研究，但第二种类型的神经元内包涵体，称为Bunina体，也与MND有关，但尚未得到适当的证实。