Optical modeling of visual corrections

视觉矫正的光学建模

• 批准号: 6860866
• 负责人: PETE S KOLLBAUM
• 金额: $ 14.4万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6860866
• 关键词: clinical research; contact lens; cornea; disease /disorder model; human subject; keratinocyte; keratoconus; lens; model design /development; optics; patient oriented research; vision

DESCRIPTION (provided by applicant): The primary goal of this K23 proposal is to train Pete S. Kollbaum, OD as an independent clinician-scientist. This training plan emphasizes mentoring in advanced polychromatic optical modeling and vision science, as well as advanced training in biostatistics and epidemiology. It will span 2 years of a Ph.D. program, followed by a 2-year post-doctoral training program. Concurrent with this, a 3-year MPH program will be completed (total of 4 years training). According to the recently published NEI "National Plan for Eye and Vision Research" (November 2003) a corneal disease program goal is to "apply the knowledge acquired from discoveries in basic science" for the treatment of these diseases (e.g., keratoconus). The estimated prevalence of keratoconus is 54.5 per 100,000 (Kennedy, Bourne et al. 1986). However, currently the most common and sometimes only treatment option for keratoconic eyes is contact lens correction. However, even with these corrections the attainable vision is still well below average due to residual aberration. Therefore, the long-term goal of this project is to develop adaptable non-surgical methods to achieve wavefront corrected optics and enhanced visual performance for both eyes with normal levels of aberration (normal) and pathological eyes with high amounts of aberration (keratoconic) eyes. Polychromatic optical models will be developed using soft and gas permeable contact lenses specifically designed to decrease (aberration-reducing) or increase (multifocal) the eye + lens aberrations. Quantification of the optical characteristics of the naked eye, the ex-vivo contact lens, the corneal shape, and the real-time contact lens position will be used. The models will be validated comparing the model predictions to the real-time whole eye aberrometry results and to the achieved polychromatic visual function. These models will have general applicability to other diseased conditions in which visual performance is degraded due to increased optical aberrations.

描述（由申请人提供）：本K23提案的主要目标是培训Pete S。Kollbaum，OD作为独立的临床科学家。该培训计划强调高级多色光学建模和视觉科学的指导，以及生物统计学和流行病学的高级培训。它将跨越2年的博士学位。计划，其次是为期2年的博士后培训计划。与此同时，一个为期3年的MPH计划将完成（共4年的培训）。根据最近出版的NEI“国家眼睛和视力研究计划”（2003年11月），角膜疾病计划的目标是“应用从基础科学发现中获得的知识”来治疗这些疾病（例如，圆锥角膜）。圆锥角膜的估计患病率为54.5/100，000（Kennedy，Bourne et al. 1986）。然而，目前圆锥角膜眼最常见且有时唯一的治疗选择是接触透镜矫正。然而，即使有了这些矫正，由于残余像差，可达到的视力仍然远低于平均水平。因此，该项目的长期目标是开发适应性强的非手术方法，以实现波前校正光学系统，并增强具有正常像差水平（正常）的眼睛和具有高像差量（圆锥角膜）的病理眼睛的视觉性能。多色光学模型将使用专门设计用于减少（减少像差）或增加（多焦点）眼睛+透镜像差的软性透气性角膜接触镜开发。将使用裸眼、离体接触透镜、角膜形状和实时接触透镜位置的光学特性的量化。将通过比较模型预测与实时全眼像差测量结果和所实现的多色视觉功能来验证模型。这些模型将普遍适用于由于光学像差增加而导致视觉性能下降的其他疾病。