Genetics, Exposures, and RA-Related Autoimmunity

描述（由申请人提供）：候选人的职业目标：在这个奖项结束时，候选人计划已经开发了必要的技能，是一个独立的临床研究者在免疫发病机制和自身免疫领域。他的长期职业目标是利用在此期间获得的培训留在学术环境中，作为独立研究人员参与创建一个新的自身免疫性疾病范例，其中疾病的易感性是在临床前状态下确定的，早期措施可以阻止疾病的发作或早期进展。 研究职业发展计划：在此奖项期间，将有两个主要组成部分，以候选人的研究培训。首先是候选人通过博士学位参加临床研究的正规教育。在临床科学计划提供了在科罗拉多大学健康科学中心。第二个将是候选人在导师V. Michael Holers和Jill Norris的指导下参与NIH资助的风湿性关节炎病因学研究项目（SERA）。 研究项目描述：在此奖项期间，候选人的 参与研究的重点将是SERA项目的一个分支， HLA等位基因、环境暴露和RA相关自身免疫性发展之间的关系，在一个队列中，大约2700名健康的RA一级亲属中进行。 RA患者候选人和更大的SERA项目的长期目标是确定RA的潜在病因机制，以及开发一个模型， 预测健康受试者中疾病的发展，最终选择将成为预防或非常早期治疗干预的候选者的受试者。

DESCRIPTION (provided by applicant): Candidate's Career Goals: At the end of this award, the candidate plans to have developed the skills necessary to be an independent clinical investigator in the field of immunopathogenesis and autoimmunity. His long-term career goal is use the training acquired during this award period to remain in an academic setting, participating as an independent researcher in the creation of a new paradigm in autoimmune disease where susceptibility to disease is determined in the pre-clinical state, and early measures can be halt the onset or early progression of disease. Research Career Development Plan: During the period of this award, there will be two major components to the candidate's research training. The first will be the candidate's participation in formal education in clinical research through the Ph.D. Program in Clinical Science offered at the University of Colorado Health Sciences Center. The second will be the candidate's involvement in the NIH-funded project Studies of the Etiologies of Rheumatoid Arthritis (SERA), under the guidance of mentors V. Michael Holers and Jill Norris. Description of Research Project: During the period of this award, the candidate's involvement in research will focus on an arm of the SERA project evaluating the relationship between HLA alleles, environmental exposures, and the development of RA- related autoimmunity in a cohort of approximately 2700 healthy first-degree relatives of patients with RA. The long-term goals of both the candidate and the larger SERA project are to identify potential etiologic mechanisms for RA, as well as to develop a model for predicting the development of disease in healthy subjects, ultimately selecting subjects who would be candidates for preventive or very early therapeutic interventions.