Core 1

核心1

• 批准号: 10700079
• 负责人: Kevin Deane
• 金额: $ 22.62万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700079
• 关键词: Address; Area; Autoimmune Diseases; Awareness; Biological Markers; Biology; Blood; Budgets; Chronic; Clinical; Clinical Research; Collection; Colorado; Data; Data Science; Development; Diagnosis; Dietary intake; Disease; Environmental Exposure; Evaluation; Future; Human Subject Research; Immunobiology; Individual; Inflammation; Inflammatory Bowel Diseases; Institutional Review Boards; Insulin-Dependent Diabetes Mellitus; Joints; Leadership; Medical History; Mind; Mucosal Immune System; Mucous Membrane; Natural History; Organ; Outcome; Outcome Assessment; Pain; Pathogenesis; Performance; Personal Satisfaction; Phase; Population Sciences; Prevention; Prevention strategy; Process; Reporting; Research; Research Design; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Role; Sampling; Self Tolerance; Series; Site; Spondylarthritis; Symptoms; Tobacco use; Training; Universities; Work; biobank; career; catalyst; cohort; data management; data repository; data sharing networks; didactic education; disease natural history; dysbiosis; innovation; lectures; member; mucosal site; outreach; predictive marker; programs; recruit; skills; social media; website development

An emerging understanding of the natural history of rheumatic disease where a ‘pre-disease’ state can be identified has led to completed prevention studies in several rheumatic and autoimmune diseases (e.g. type 1 diabetes, rheumatoid arthritis), with many other trials underway. The emergence of potential prevention strategies in rheumatic and autoimmune diseases highlights the importance of fully understanding the mechanisms underlying the development of these diseases, from their initiation with being positive for a predictive biomarker yet without target organ involvement through to the phase(s) of clinically-apparent disease and extensive organ damage. Importantly, as a result of research advances over the past several years, including a number made by members of this University of Colorado (CU) Rheumatic Disease Research Resource Center (RDRRC) proposal, a hypothesis now exists for a key role of chronic inflammation and dysbiosis within the mucosal immune system as a catalyst for both the initial break in self-tolerance in asymptomatic individuals as well as a continued driver to clinical disease development and increasing target organ damage. Exploration of this hypothesis across rheumatic and autoimmune diseases through multiple evolving stages of disease, and the integration of multiple sites within the body (e.g. blood, mucosal sites, and joints), requires special skill sets in study design, assessments such as subject-reported outcomes (e.g. pain, well-being) and environmental exposures (e.g. dietary intake, tobacco use), biospecimen collection and processing (including blood and mucosal samples), and analyses. To address these important issues, the role of the RDRRC Resource Core 1: Population and Data Sciences is to provide advisory support for high-quality studies in rheumatic disease as well as unique access to banked data and biospecimens as well as ‘living biorepositories’ of informative subjects. These activities will facilitate research into the natural history of rheumatic disease around the role of mucosal processes. Importantly, the Core’s activities are also expected to recruit new investigators into this area by providing the support and materials necessary to facilitate their awareness and research opportunities. In aggregate, these activities as well as the other RDRRC activities should advance the field in terms of understanding disease pathogenesis, diagnosis and treatment, as well as actionable prevention of rheumatic disease.

对风湿性疾病自然史的新认识，其中“疾病前”状态可以是 已确定导致完成了几种风湿性和自身免疫性疾病（如1型）的预防研究 糖尿病、类风湿性关节炎），许多其他试验正在进行中。潜在预防的出现 风湿性和自身免疫性疾病的治疗策略强调了充分了解 这些疾病发展的潜在机制，从它们开始时呈阳性， 预测性生物标志物，但不涉及靶器官，直至临床明显疾病阶段 和大面积器官损伤重要的是，由于过去几年的研究进展， 其中包括科罗拉多大学风湿病研究所成员的一系列研究 资源中心（RDRRC）的建议，一个假设，现在存在的一个关键作用，慢性炎症和 粘膜免疫系统内的生态失调作为自身耐受性的初始破坏和免疫耐受性的初始破坏的催化剂， 无症状个体以及临床疾病发展的持续驱动因素， 器官损伤通过多种方法在风湿性和自身免疫性疾病中探索这一假说 疾病的发展阶段，以及体内多个部位（例如血液、粘膜部位和 关节），需要研究设计中的特殊技能，评估如受试者报告的结果（例如疼痛， 健康）和环境暴露（如饮食摄入、烟草使用）、生物标本采集和 处理（包括血液和粘膜样本）和分析。为了解决这些重要问题， RDRRC资源核心1：人口和数据科学是为高质量的 风湿性疾病的研究以及对银行数据和生物标本的独特访问， 信息主题的生物储存库。这些活动将促进对自然历史的研究， 风湿病周围黏膜突起的作用。重要的是，核心小组的活动预计还将 通过提供必要的支持和材料，为这一领域招募新的调查人员， 认识和研究机会。总的来说，这些活动以及恢复民主与和解委员会的其他活动 应该在理解疾病发病机制、诊断和治疗方面推进该领域， 风湿性疾病的有效预防。