Aerosolized PGE1 in Neonatal Pulmonary Hypertension
Aerosolized PGE1 in Neonatal Pulmonary Hypertension
批准号:
6867317
负责人:
BEENA G. SOOD
金额:
$2.57万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-04-01 至 2008-03-31
关键词:
clinical trial phase Iclinical trialsdosagedrug screening /evaluationhuman subjectinhalation drug administrationnewborn human (0-6 weeks)oximetrypatient oriented researchpediatric pharmacologypostdoctoral investigatorprostaglandin Epulmonary circulationpulmonary hypertensionrespiratory oxygenationrespiratory therapyvascular resistancevasodilators
中文摘要
描述(由申请人准备):候选人Beena Sood MD是
有兴趣在新生儿-围产期医学领域从事学术事业,
以患者为导向的研究。感兴趣的领域是使用
雾化药物I新生儿、肺生物学和药理学
肺血管和动脉导管的操作。候选
在她的奖学金培训期间一直积极参与研究。的
韦恩州立大学的机构环境提供了广泛的
新生儿-围产期司
医疗服务在Hutzel医院和儿童医院都很忙碌。
密歇根职业发展计划包括正式的指导,广泛的
临床研究设计硕士课程,
统计分析,临床和补充实验室的实施
与患者导向研究相关的研究。苏德博士的导师西莎
Shankaran,MD,是一位著名的生物学家,在
涉及多个多中心临床的临床研究设计
通过NICHD新生儿研究网络进行试验。她已经建立
与整个密歇根州的植物学家和
这将有助于Sood博士提出的研究。JV Aranda医学博士、博士
和V Delaney-Black医学博士,公共卫生硕士将担任这项研究的顾问。苏德博士建议
使用雾化前列腺素E1(PGE 1)作为
选择性肺血管扩张剂治疗持续性肺动脉高压
新生儿高血压(PPHN)。这是研究计划的两个阶段。
最初,在足月儿和近足月儿中进行的PGE 1雾化吸入的I期初步研究
与PPHN将在密歇根州儿童医院进行(已经
正在进行中)与底特律地区的其他医院合作,
确定PGE 1的适当剂量。在第二阶段,
前列腺素E_1(PGE_1)雾化吸入治疗前列腺癌的最佳剂量的对照研究
将对这些单位进行评估,以评价疗效。如果有效,
使用雾化PGE 1治疗新生儿PPHN作为一项多中心研究,
NICHD新生儿网络。
英文摘要
DESCRIPTION (prepared by applicant): The candidate, Beena Sood MD, is
interested in pursuing an academic career in Neonatal-Perinatal medicine with
the focus on patient oriented research. The areas of interest are the use of
aerosolized medications I newborn, pulmonary biology, and pharmacologic
manipulation of the pulmonary vasculature and ductus arteriosus. The candidate
has been actively involved in research during her fellowship training. The
institutional environment at the Wayne State University offers extensive
resources available to the candidate The Division of Neonatal-Perinatal
Medicine has a busy service both at Hutzel Hospital and Children's Hospital of
Michigan. The career development plan includes formal mentorship, extensive
coursework leading to a Master's of Science degree in Clinical Research Design and
Statistical Analysis, conduct of clinical and complementary laboratory
research related to the patient-oriented research. Dr. Sood's mentor, Seetha
Shankaran, MD, is a renowned neonatologist with extensive experience in
clinical research study design involved in several Multi center clinical
trials through the NICHD Neonatal Research Network. She has established
collaborative relationships with neonatologists throughout Michigan and the
U.S. that will facilitate the studies proposed by Dr. Sood. JV Aranda MD, PhD
and V Delaney-Black MD, MPH will be Consultants on the study. Dr Sood proposes
a clinical trial for the use of aerosolized prostaglandin E1 (PGE1) as a
selective pulmonary vasodilator in the treatment of persistent pulmonary
hypertension (PPHN) in the newborn. T are two phases of the research plan.
Initially, a phase I pilot study of aerosolized PGE1 in term and near- infants
with PPHN will be conducted at the Children's Hospital of Michigan (already
under way) in collaboration with other hospitals in the Detroit area to
establish the appropriate dosing of PGEl. In the second phase, a randomized
controlled study of the optimum dose of aerosolized Prostaglandin E1 (PGE1) in
the units will be conducted to evaluate efficacy. If effective, a proposal for
using aerosolized PGE1 in neonatal PPHN as a multicenter study will be
submitted to the NICHD Neonatal Network.
期刊论文(6)
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DOI:
10.1016/j.phrs.2007.09.017
发表时间:
2007-12
期刊:
Pharmacological research
影响因子:
9.3
作者:
[B. Sood;J. Peterson;M. Malian;R. Galli;Maria Geisor-Walter;J. Mckinnon;J. Sharp;K. Maddipati]
通讯作者:
B. Sood;J. Peterson;M. Malian;R. Galli;Maria Geisor-Walter;J. Mckinnon;J. Sharp;K. Maddipati
Toxicity of prolonged high dose inhaled PGE1 in ventilated neonatal pigs.
长期高剂量吸入 PGE1 对通气新生猪的毒性。
DOI:
10.1016/j.pupt.2008.01.011
发表时间:
2008
期刊:
Pulmonary pharmacology & therapeutics
影响因子:
3.2
作者:
[Sood,BeenaG, Dawe,ElizabethJ, Maddipati,KrishnaRao, Malian,Monica, Chen,Xinguang, Galli,Robert, Rabah,Raja]
通讯作者:
Rabah,Raja
Effect of aerosolized PGE(1) on the ductus arteriosus of neonatal swine.
雾化PGE(1)对新生猪动脉导管的影响。
DOI:
10.1016/j.prostaglandins.2009.08.002
发表时间:
2009
期刊:
Prostaglandins & other lipid mediators
影响因子:
2.9
作者:
[Sood,BeenaG, Chintala,Kavitha, Wykes,Susan, Gurczynski,Joellyn, Chen,Xinguang, Rabah,Raja]
通讯作者:
Rabah,Raja
Aerosol delivery during high frequency jet ventilation: an MRI evaluation.
高频喷射通气期间的气溶胶输送:MRI 评估。
DOI:
10.4187/respcare.01746
发表时间:
2012
期刊:
Respiratory care
影响因子:
2.5
作者:
[Sood,BeenaG, Latif,Zahid, Shen,Yimin, Galli,RobertJ, Dunlap,CharlesW, Gelmini,MatthewJ, Haacke,EMark]
通讯作者:
Haacke,EMark
Aerosolized PGE1: a selective pulmonary vasodilator in neonatal hypoxemic respiratory failure results of a Phase I/II open label clinical trial.
雾化 PGE1:一种选择性肺血管扩张剂,用于治疗新生儿低氧性呼吸衰竭,I/II 期开放标签临床试验结果。
DOI:
10.1203/01.pdr.0000139927.86617.b6
发表时间:
2004
期刊:
Pediatric research
影响因子:
3.6
作者:
[Sood,BeenaG, Delaney-Black,Virginia, Aranda,JacobV, Shankaran,Seetha]
通讯作者:
Shankaran,Seetha
Phase 1/2 Study of Aerosolized Survanta for the Treatment of Neonatal Respiratory Distress Syndrome
-
批准号:8751848
-
项目类别:
-
资助金额:$39.64万
-
财政年份:2014
-
负责人:BEENA G. SOOD
-
依托单位:
Phase 1/2 Study of Aerosolized Survanta for the Treatment of Neonatal Respiratory Distress Syndrome
-
批准号:9316340
-
项目类别:
-
资助金额:$20.37万
-
财政年份:2014
-
负责人:BEENA G. SOOD
-
依托单位:
Phase 1/2 Study of Aerosolized Survanta for the Treatment of Neonatal Respiratory Distress Syndrome
-
批准号:9099512
-
项目类别:
-
资助金额:$39.99万
-
财政年份:2014
-
负责人:BEENA G. SOOD
-
依托单位:
Aerosolized PGE1 in Neonatal Pulmonary Hypertension
-
批准号:6620356
-
项目类别:
-
资助金额:$12.34万
-
财政年份:2002
-
负责人:BEENA G. SOOD
-
依托单位:
Aerosolized PGE1 in Neonatal Pulmonary Hypertension
-
批准号:6725523
-
项目类别:
-
资助金额:$12.63万
-
财政年份:2002
-
负责人:BEENA G. SOOD
-
依托单位:
Aerosolized PGE1 in Neonatal Pulmonary Hypertension
-
批准号:6416082
-
项目类别:
-
资助金额:$12.49万
-
财政年份:2002
-
负责人:BEENA G. SOOD
-
依托单位:
海外基金