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Preemptive Analgesia in Recovery from Hysterectomy

子宫切除术后恢复中的超前镇痛

基本信息

批准号：
6946918
负责人：
EDWARD A OCHROCH
金额：
$ 13万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-11 至 2007-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6946918
关键词：
chronic pain clinical trials epidural anesthesia female human subject human therapy evaluation hysterectomy outcomes research patient care management patient oriented research postoperative complications women&apos s health

项目摘要

DESCRIPTION (provided by applicant): Over half of the over 23 million surgical procedures are accompanied by inadequately treated pain. Pain interferes with bodily functions such as breathing, blood pressure regulation, digestion etc. It inhibits the patient s ability to participate in postoperative care regimens, and clearly increases the risk of postoperative respiratory complications. After discharge, the poorly controlled pain continues to plague patients. The pain associated with surgery can lead to chronic pain syndromes due to sensitization of the central nervous system (CNS). We have chosen to use trans-abdominal hysterectomy (TAH) as a model operation because 600,000 women a year have hysterectomies, and women are more prone to suffering chronic painful syndromes. Preemptive analgesia is an intervention designed to decrease pain and improve patient recovery from surgery by initiating an analgesic regimen prior to the onset of the painful stimuli. There is clear animal based research and a growing body of human clinical research that preemptive analgesia can reduce pain and analgesic needs following surgery. Recent work has extended the proof of benefits in the form of decreased pain and increased activity to well after discharge from the hospital. This research application proposes to examine the short- and long-term benefits of aggressive preemptive epidural analgesia in patients undergoing TAR Pain during hospitalization and after discharge, activity levels, and return to preoperative function will be quantitatively assessed with validated outcome measures. Dr. Ochroch, an Assistant Professor of Anesthesiology at the University of Pennsylvania, is applying for a Clinical Investigator Award (K23) to pursue an academic career focusing on improving recovery from surgery. He has a serious interest in this area as evidenced by his involvement in current and proposed research. This application requests support to allow him to undertake a comprehensive career development program including: 1) a Masters in Biostatistics and Epidemiology under the mentorship of Dr. Brian Strom, 2) a research preceptor ship with Drs. John Farrar and Allan Gottschalk and Mark Morgan, and 3) the proposed research project. These activities will provide him with the skills and experience to pursue a successful career of meaningful funded research as an independent investigator.

描述(申请人提供)：2300多万人中的一半以上外科手术伴随着治疗不当的疼痛。疼痛干扰身体功能，如呼吸、血压调节、消化等。它抑制了患者S的参与能力术后护理方案，并明显增加术后风险呼吸道并发症。出院后，疼痛控制不佳继续困扰着病人。与手术相关的疼痛可能导致中枢神经系统敏感化引起的慢性疼痛综合征 (CNS)。我们选择了经腹子宫切除术(TAH)作为模型手术是因为每年有60万妇女做子宫切除术，而且妇女更多容易患上慢性疼痛综合症。超前止痛是一种旨在减轻疼痛和改善疼痛的干预措施患者在手术前开始止痛方案以从手术中恢复疼痛刺激的开始。有明确的基于动物的研究和一个越来越多的人类临床研究表明，超前镇痛可以减少手术后需要止痛和止痛药。最近的研究扩大了这一证明以减轻疼痛和增加活动量的形式带来的好处出院了。此研究应用程序建议检查硬膜外积极超前镇痛的近期和远期疗效住院期间和出院后出现焦油疼痛的患者，活动水平，并恢复到术前功能将是定量的使用经过验证的结果衡量标准进行评估。奥罗奇博士是加州大学麻醉学助理教授宾夕法尼亚州正在申请临床研究员奖(K23)，以追求学术生涯专注于提高手术后的康复水平。他有一个严重的他对这一领域的兴趣体现在他参与了当前和拟议的研究。此应用程序请求支持以允许他进行全面的职业发展计划，包括：1)硕士学位生物统计学和流行病学在Brian Strom博士的指导下，2)a 与John Farrar博士、Allan Gottschalk博士和Mark博士一起的研究导师船以及3)拟议的研究项目。这些活动将提供他拥有的技能和经验对他追求成功的职业生涯是有意义的以独立调查员的身份资助研究。